Related Experiment Video

Updated: Feb 2, 2026

Single-Step Enrichment of a TAP-Tagged Histone Deacetylase of the Filamentous Fungus Aspergillus nidulans for Enzymatic Activity Assay
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Single-Step Enrichment of a TAP-Tagged Histone Deacetylase of the Filamentous Fungus Aspergillus nidulans for Enzymatic Activity Assay

Published on: May 1, 2019

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Therapeutic potential of selective histone deacetylase 3 inhibition

Lihui Zhang1, Yiming Chen2, Qixiao Jiang3

  • 1School of Stomatology, Weifang Medical University, Weifang, Shandong, China.

European Journal of Medicinal Chemistry
|November 26, 2018
PubMed

Insights

Selective inhibition of Histone Deacetylases (HDACs), particularly HDAC3, shows promise for treating various diseases like cancer. HDAC3 inhibitors offer targeted therapy with improved safety and fewer side effects.

Area of Science:

  • Biochemistry
  • Pharmacology
  • Epigenetics

Background:

  • Histone deacetylases (HDACs) are implicated in diseases including cancer, inflammation, and neurodegeneration.
  • HDAC inhibitors are crucial for treating epigenetic abnormalities, especially in oncology.
  • Isoform-selective inhibitors offer enhanced specificity and safety profiles.

Purpose of the Study:

  • To review the therapeutic potential of selective HDAC3 inhibition.
  • To highlight HDAC3's specific role in disease development.
  • To explore prospects for HDAC3-targeted drug development.

Main Methods:

  • Literature review of HDAC3's role in disease.
  • Analysis of current HDAC3 inhibitor research.
  • Evaluation of drug development strategies for selective HDAC3 inhibition.

Main Results:

  • HDAC3 plays a distinct role in several disease pathologies.
  • Selective HDAC3 inhibition demonstrates potential for targeted therapeutic interventions.
  • Development of isoform-specific HDAC inhibitors is a key focus.

Conclusions:

  • Targeted inhibition of HDAC3 presents a promising avenue for novel drug development.
  • Selective HDAC3 inhibitors may offer improved efficacy and safety over non-selective agents.
  • Further research into HDAC3-selective therapies is warranted for various diseases.
Keywords:
Cardiovascular diseaseDiabetesHDAC3 selective inhibitorInflammationNeurodegenerative diseaseTumor

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