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Deep Sclerectomy with Porous Collagen in Open-angle Glaucoma, Short-term Study
Ahmed Elbably1, Tageldin M Othman2, Ahmed Mousa3
1Anterior Segment and Glaucoma Specialist, Magrabi Eye Hospital, Riyadh, Kingdom of Saudi Arabia.
Journal of Current Glaucoma Practice
|November 27, 2018
Summary
Porous collagen enhances deep sclerectomy (DS) outcomes in open-angle glaucoma by significantly reducing intraocular pressure (IOP). This implant allows DS even with trabeculo-Descemet membrane (TDM) rupture, avoiding conversion to trabeculectomy.
Area of Science:
- Ophthalmology
- Glaucoma Surgery
- Biomaterials
Background:
- Open-angle glaucoma requires effective surgical interventions to control intraocular pressure (IOP).
- Deep sclerectomy (DS) is a surgical procedure to lower IOP.
- The use of porous collagen implants in glaucoma surgery is an area of ongoing research.
Purpose of the Study:
- To evaluate the efficacy of porous collagen implants in deep sclerectomy (DS).
- To assess the role of porous collagen in DS, specifically in cases with and without trabeculo-Descemet membrane (TDM) rupture.
- To determine the impact of porous collagen on intraocular pressure (IOP) reduction in open-angle glaucoma patients.
Main Methods:
- A study involving 46 eyes of patients with open-angle glaucoma and medically uncontrolled IOP.
- Deep sclerectomy (DS) was performed on all participants.
- Ologen, a porous collagen implant, was used in the scleral lake and subconjunctival space, with or without TDM rupture.
Main Results:
- Pre-operative mean IOP was 25.6 ± 10.6 mm Hg, reduced to 12.1 ± 3 mm Hg at 12 months post-surgery.
- Overall mean IOP reduction was 48.3% ± 21.3%.
- No significant difference in IOP reduction was observed between cases with TDM rupture and those without (p = 0.689).
Conclusions:
- Porous collagen implantation can improve the outcomes of deep sclerectomy (DS).
- The use of porous collagen facilitates DS in cases with TDM rupture, preventing the need for conversion to trabeculectomy.
- Porous collagen shows promise as an adjunct in glaucoma surgery.
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