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Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Cerenkov Luminescence Imaging CLI for Cancer Therapy Monitoring
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Antiangiogenic Gene Therapy in Cancer.

L Zhang1, Q R Chen1, A J Mixson1

  • 1Department of Pathology, University of Maryland at Baltimore, MD 21201.

Current Genomics
|November 27, 2018
PubMed
Summary
This summary is machine-generated.

Antiangiogenic gene therapy targets tumor blood supply, inhibiting growth by blocking new blood vessel formation. Advances in delivery systems are crucial for clinical application of this promising cancer treatment.

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Area of Science:

  • Oncology
  • Molecular Biology
  • Gene Therapy

Background:

  • Tumor angiogenesis, the development of new blood vessels supplying tumors, is a critical target for cancer treatment.
  • Antiangiogenic gene therapy offers a novel approach by targeting tumor vasculature, which is often accessible via systemic administration.
  • Unlike other gene therapies where tumor vasculature can be a barrier, it serves as a target for antiangiogenic strategies.

Purpose of the Study:

  • To review the mechanisms of angiogenesis and antiangiogenesis in the context of cancer.
  • To discuss the current status and future directions of antiangiogenic gene therapy.
  • To highlight the potential of targeting tumor vasculature for cancer treatment.

Main Methods:

  • Review of pre-clinical studies utilizing gene-based viral and non-viral therapies.
  • Analysis of gene-encoded antiangiogenic polypeptides (e.g., angiostatin, endostatin).
  • Investigation of strategies targeting angiogenic growth factors (e.g., VEGF) or their receptors.

Main Results:

  • Gene therapies encoding antiangiogenic proteins like angiostatin and endostatin have shown significant tumor growth inhibition in pre-clinical models.
  • Targeting angiogenic factors or receptors, such as vascular endothelial growth factor (VEGF), using antisense methods or decoy receptors has proven effective.
  • These approaches can induce a dormant state in tumors by inhibiting extracellular angiogenesis.

Conclusions:

  • Antiangiogenic gene therapy demonstrates significant promise in pre-clinical cancer models by inhibiting tumor growth.
  • Further advancements in viral and non-viral delivery systems are essential for the clinical translation of antiangiogenic gene therapy.
  • Targeting tumor angiogenesis represents a viable and exciting frontier in cancer gene therapy research.