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Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
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Effect of Myricetin on Primary Open-angle Glaucoma
Qing Yang1, Ying Li1, Lin Luo1
1Department of Ophthalmology, Qingdao Municipal Hospital, Qingdao 266011, China.
Translational Neuroscience
|November 27, 2018
Summary
Myricetin demonstrates protective effects for primary open angle glaucoma (POAG) by reducing oxidative stress and inflammation in trabecular meshwork cells. This natural compound also helped prevent intraocular pressure elevation in a rat glaucoma model.
Area of Science:
- Ophthalmology
- Cell Biology
- Pharmacology
Background:
- Primary open angle glaucoma (POAG) is a leading cause of vision loss, characterized by retinal ganglion cell death.
- Its multifactorial etiology necessitates research into novel therapeutic targets like myricetin.
Purpose of the Study:
- To investigate the protective effects of myricetin on trabecular meshwork (TM) cells in the context of POAG.
- To evaluate myricetin's impact on oxidative stress, inflammation, and cellular senescence in POAG TM cells and its in-vivo efficacy.
Main Methods:
- An in-vivo rat model of glaucoma was established using hyaluronic acid injections.
- Rats received daily oral gavage of myricetin (25, 50, or 100 mg/kg) for six weeks.
- POAG TM cells were exposed to varying concentrations of myricetin (25, 50, or 100 μM) in vitro.
Main Results:
- Myricetin treatment significantly reduced reactive oxidative species (ROS) and lipid peroxidation in POAG TM cells.
- Expressions of TGFβ1/β2, VEGF, and senescence markers (SA-β-gal, p16, p21) were downregulated by myricetin.
- Myricetin administration prevented intraocular pressure (IOP) elevation and decreased inflammatory cytokines in glaucoma-induced rats.
Conclusions:
- Myricetin exhibits significant protective effects against glaucomatous changes in TM cells.
- The findings suggest myricetin as a potential therapeutic agent for managing POAG.
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