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Dietary plant miRNAs as an augmented therapy: cross-kingdom gene regulation

Sanchita1, Ritu Trivedi2, Mehar Hasan Asif1,3

  • 1a Genetics and Molecular Biology Division, CSIR-National Botanical Research Institute , Lucknow, Uttar Pradesh , India.

RNA Biology
|November 27, 2018
PubMed

Insights

Orally consumed plant microRNAs (miRNAs) may regulate human gene expression, but scientific evidence remains debated. This review explores the potential and challenges of plant miRNAs in cross-kingdom gene regulation for human health applications.

Area of Science:

  • Molecular Biology
  • Genetics
  • Nutrition Science

Background:

  • Cross-kingdom gene regulation by microRNAs (miRNAs) is a growing area of research.
  • The presence and function of orally acquired plant miRNAs in the human body are debated.
  • Plant miRNAs offer potential as therapeutic agents and dietary supplements.

Purpose of the Study:

  • To review the current understanding of exogenous plant miRNA application in humans.
  • To discuss the evidence for and against cross-kingdom gene regulation by plant miRNAs.
  • To explore the therapeutic potential of plant miRNAs in treating diseases.

Main Methods:

  • Literature review of studies on plant miRNA uptake and effects in humans.
  • Analysis of experimental data regarding the detection and function of plant miRNAs in the human digestive and circulatory systems.
  • Discussion of scientific controversies and technical challenges in the field.

Main Results:

  • Evidence suggests plant miRNAs can be orally acquired and detected in the human alimentary canal.
  • The biological significance and functional consequences of this cross-kingdom regulation are still under investigation.
  • Concerns exist regarding potential technical flaws in studies supporting cross-kingdom regulation.

Conclusions:

  • Plant miRNAs hold promise for novel therapeutic strategies and dietary applications.
  • Further research is needed to validate the efficacy and safety of plant-derived miRNAs for human health.
  • Clarifying the mechanisms and impact of cross-kingdom gene regulation is crucial for future development.
Keywords:
cross-kingdomdietary intakeexogenousgene expression regulationmiRNAtherapeutics

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