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Related Experiment Videos

Pancreatic endocrine function in cirrhotic rats.

T Nakamura1, M Otsuki, S Tani

  • 1Second Department of Internal Medicine, Kobe University School of Medicine, Japan.

Metabolism: Clinical and Experimental
|September 1, 1988
PubMed
Summary

Liver cirrhosis in rats alters pancreatic hormone levels, with lower insulin and higher glucagon. In vitro studies show reduced glucose-stimulated insulin secretion but normal cell sensitivity.

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Area of Science:

  • Endocrinology
  • Hepatology
  • Gastroenterology

Background:

  • Liver cirrhosis significantly impacts systemic metabolic regulation.
  • Pancreatic endocrine dysfunction is a known complication of advanced liver disease.

Purpose of the Study:

  • To investigate the in vivo and in vitro pancreatic endocrine function in a rat model of liver cirrhosis.
  • To assess insulin and glucagon secretion and pancreatic hormone content in cirrhotic rats.

Main Methods:

  • Liver cirrhosis induced using carbon tetrachloride in rats.
  • In vivo analysis of jugular and portal venous blood for insulin and glucagon levels.
  • In vitro studies using isolated perfused pancreata to measure hormone secretion in response to stimuli.

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Main Results:

  • Cirrhotic rats exhibited lower pancreatic insulin content and higher glucagon content.
  • In vivo, peripheral insulin was higher, portal insulin lower, and both peripheral and portal glucagon were higher in cirrhotic rats.
  • In vitro, cirrhotic pancreata showed reduced insulin secretion to glucose and cholecystokinin-octapeptide, but normal arginine-stimulated insulin release.
  • Glucagon secretion in response to arginine was elevated in cirrhotic rats.

Conclusions:

  • Liver cirrhosis in rats leads to significant alterations in pancreatic endocrine function.
  • Despite altered secretion patterns, pancreatic islet cell sensitivity to glucose and cholecystokinin-octapeptide appears preserved.