Related Experiment Video

Updated: Feb 2, 2026

Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice
06:35

Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice

Published on: June 28, 2021

4.6K

The diagnostic values of procalcitonin and interleukin 6 in acute appendicitis

Alireza Rastgoo Haghi1, Amir Kasraianfard2, Alireza Monsef1

  • 1Department of Pathology, Hamadan University of Medical Sciences, Hamadan, Iran.

Turkish Journal of Surgery
|November 27, 2018
PubMed

Insights

Diagnosing acute appendicitis remains challenging. Measuring procalcitonin and interleukin-6 (IL-6) together improves diagnostic accuracy, reducing unnecessary appendectomies.

Area of Science:

  • Medical diagnostics
  • Biomarker research
  • Surgical pathology

Background:

  • Acute appendicitis diagnosis is often inaccurate, even with advanced imaging.
  • Misdiagnosis poses risks, particularly for children and the elderly, due to rapid progression and potential for perforation.
  • Accurate and timely diagnosis is critical to prevent severe complications and mortality.

Purpose of the Study:

  • To evaluate the diagnostic utility of procalcitonin and interleukin-6 (IL-6) in identifying acute appendicitis.
  • To assess the combined diagnostic performance of these biomarkers.
  • To determine if these markers can reduce negative appendectomy rates.

Main Methods:

  • Prospective study of patients suspected of acute appendicitis in an urban tertiary care hospital.
  • Blood samples collected pre-appendectomy for procalcitonin and IL-6 level analysis.
  • Histopathological examination of resected appendix for definitive diagnosis.

Main Results:

  • Histopathology confirmed acute appendicitis in 75% of 80 patients.
  • Procalcitonin sensitivity was 65% (specificity 80%); IL-6 sensitivity was 76% (specificity 55%).
  • Concurrent measurement of procalcitonin and IL-6 achieved 95% sensitivity and 55% specificity.

Conclusions:

  • Combined analysis of procalcitonin and IL-6 offers improved diagnostic accuracy for acute appendicitis.
  • Parallel measurement of these biomarkers can help decrease the rate of unnecessary negative appendectomies.
  • This approach may enhance diagnostic efficiency in emergency settings.
Abstract

More Related Videos

Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model05:41

Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model

Published on: April 6, 2022

3.5K
Mouse Model of Oleic Acid-Induced Acute Respiratory Distress Syndrome04:45

Mouse Model of Oleic Acid-Induced Acute Respiratory Distress Syndrome

Published on: June 2, 2022

2.8K

Related Concept Videos

Appendicitis-II: Diagnostic Studies and Management01:29

Appendicitis-II: Diagnostic Studies and Management

Diagnosing and managing appendicitis requires a structured and comprehensive approach that spans from initial assessment to postoperative care. Here is an overview of the process:
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...
572
Appendicitis-I: Introduction01:22

Appendicitis-I: Introduction

The appendix, a small, narrow, blind tube extending from the inferior part of the cecum, is widely regarded as a vestigial organ, having lost much of its original function through evolution. Despite its diminished role, the appendix can become inflamed, a condition known as appendicitis.
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
2.5K
Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
408
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
271
Biodiversity and Human Values01:24

Biodiversity and Human Values

Human civilization relies on biodiversity in many ways. Sudden changes in species biodiversity result in environmental changes that can modify weather patterns and therefore human civilizations.
17.1K
Professional Values01:29

Professional Values

Nurses are responsible for caring for patients during birth, death, illness, and healing. Professional values guide the decisions and actions that nurses make in their careers. If nurses know the decisions and actions to take, providing patients with exceptional care is possible.
The values that are the foundation of the nursing profession are altruism, autonomy, human dignity, and social justice.
First, altruism refers to the concern for the welfare and well-being of others without personal...
10.7K