Related Experiment Video
Updated: Feb 2, 2026

The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool
Published on: June 30, 2014
Interferon-beta treated-multiple sclerosis patients exhibit a decreased ratio between immature/transitional B cell
Andreia Monteiro1, Catarina Cruto2, Pedro Rosado2
1Centro de Investigação em Ciências da Saúde, Universidade da Beira Interior (CICS-UBI), Avenida Infante D. Henrique, Covilhã 6200-506, Portugal; Serviço Patologia Clínica, Centro Hospitalar Universitário Cova da Beira, Quinta do Alvito, 6200-251 Covilhã, Portugal.
Abstract:
Our aim was to quantify circulating B cell subsets; immature/transitional, naïve, CD27- and CD27+ memory cells and plasmablasts, in relapsing-remitting multiple sclerosis patients treated with IFN-β. The most relevant findings were a significant increase of plasmablasts and a decrease of immature/transitional B cells, resulting in a decreased ratio between those cells in relapse RRMS, together with an increase of CD27- and CD27+IgM+ memory B cell subsets in both phases of the disease. These alterations point to an active B cell response, particularly in relapse, and the above referred ratio could constitute a good biomarker of relapse in patients that underwent IFN-β treatment.
Related Concept Videos
Properties of Transition Metals
Phase Transitions
Decreasing Function
Multiple Allele Traits
Phase Transitions: Sublimation and Deposition
Cooperative Allosteric Transitions

