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Published on: November 18, 2017
Oxidative Stress as Cause, Consequence, or Biomarker of Altered Female Reproduction and Development in the Space
Jon G Steller1, Jeffrey R Alberts2, April E Ronca3,4
1Division of Maternal Fetal Medicine, Department of Obstetrics & Gynecology, University of Colorado School of Medicine, Aurora, CO 80249, USA. jonathan.steller@ucdenver.edu.
Abstract:
Oxidative stress has been implicated in the pathophysiology of numerous terrestrial disease processes and associated with morbidity following spaceflight. Furthermore, oxidative stress has long been considered a causative agent in adverse reproductive outcomes. The purpose of this review is to summarize the pathogenesis of oxidative stress caused by cosmic radiation and microgravity, review the relationship between oxidative stress and reproductive outcomes in females, and explore what role spaceflight-induced oxidative damage may have on female reproductive and developmental outcomes.
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