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B Cribier1

  • 1Clinique dermatologique, hôpitaux universitaires de Strasbourg, 1, place de l'Hôpital, 67091 Strasbourg cedex, France.

Annales De Dermatologie Et De Venereologie
|November 28, 2018
PubMed
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Basal cell carcinoma (BCC) diagnosis is usually straightforward, but predicting histopathological subtypes like aggressive BCCs can be challenging. Identifying specific subtypes and differentiating them from similar tumors is crucial for appropriate treatment.

Area of Science:

  • Dermatopathology
  • Oncology

Background:

  • Basal cell carcinoma (BCC) is a common skin cancer with generally easy diagnosis.
  • Clinical prediction of BCC histopathological subtypes is often difficult, impacting treatment strategies.

Purpose of the Study:

  • To review the diagnostic challenges and prognostic implications of various basal cell carcinoma subtypes.
  • To highlight key differentiating features between BCC and trichoblastoma.
  • To discuss the management of aggressive BCC variants and those with specific differentiation.

Main Methods:

  • Review of histopathological criteria for BCC subtypes.
  • Discussion of immunohistochemical markers (Berp4, PHLDA1) for differential diagnosis.
  • Analysis of prognostic factors for different BCC variants.
Keywords:
Basal cellCarcinomeTrichoblastomebasocellulairecarcinomatrichoblastictrichoblastiquetrichoblastoma

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Main Results:

  • Sclerosing BCCs are frequently misclassified; trabecular and nodular subtypes are more common than morpheaform.
  • Aggressive BCC subtypes include trabecular, morpheaform, and micronodular.
  • BCC with sebaceous differentiation (sebaceomas) are associated with Muir-Torre syndrome.
  • Basosquamous BCCs require treatment similar to squamous cell carcinomas due to higher aggressiveness.

Conclusions:

  • Accurate histopathological subtyping of BCC is essential for predicting behavior and guiding treatment.
  • Distinguishing BCC from trichoblastic tumors relies on specific histopathologic and immunohistochemical features.
  • Certain BCC variants, like basosquamous and those with sebaceous differentiation, necessitate specific management approaches.