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Effect of water-soluble cinnamon extract on electrocardiographic parameters: An analysis of the CiNNaMON trial
Danielle N Pender1, Paul F Crawford2, Jill M Clark2
1Department of Pharmacy, David Grant Medical Center, Travis AFB, CA, United States.
Objective:
To ensure that cinnamon extract does not cause electrocardiographic (ECG) effects in patients with prediabetes.
Design:
A subgroup analysis was carried out on data from 103 prediabetic patients participating in the "Effect of Lifestyle Intervention Plus Water-Soluble Cinnamon Extract on Lowering Blood Glucose in Prediabetics" trial. The trial was a randomized, double-blind, placebo-controlled trial comparing cinnamon extract versus placebo in prediabetic adults who committed to participate in a standard-of-care, aggressive lifestyle therapy program.
Setting:
Family Medicine Residency, Mike O'Callaghan Military Medical Center; Family Medicine Residency, David Grant Medical Center, Travis AFB; Wilford Hall Ambulatory Surgical Center, Family Medicine Residency; Eglin AFB, Family Medicine residency; Offutt AFB, Family Medicine Residency.
Main Outcome Measures:
QTc interval, QT interval, PR interval, QRS duration and heart rate from ECGs at baseline, 3 months, and 6 months.
Results:
Analysis of the ECGs showed no time-matched intra-group differences in any of the ECG parameters (QTc interval, QT interval, PR interval, QRS duration and heart rate; all p-values >0.05).
Conclusions:
Use of cinnamon extract in prediabetic patients does not affect electrocardiographic measures.
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