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Study of Concussion in Rugby Union through MicroRNAs (SCRUM): a study protocol of a prospective, observational cohort
Kamal M Yakoub1,2, Patrick O'Halloran2, David J Davies1,2
1NIHR Surgical Reconstruction and Microbiology Research Centre, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
BMJ Open
|November 28, 2018
Summary
This study aims to find non-invasive biomarkers in saliva and urine for diagnosing sports-related concussions. These biomarkers could aid in making better return-to-play decisions for athletes after a head injury.
Area of Science:
- Sports Medicine
- Neurology
- Biomarker Discovery
Background:
- Diagnosing mild traumatic brain injury (concussion) in sports is challenging due to reliance on subjective symptom reporting.
- The absence of objective biomarkers poses health risks from missed or repetitive injuries.
- There is a critical need for reliable tools to aid concussion diagnosis and prognosis.
Purpose of the Study:
- To identify a panel of non-invasive microRNA biomarkers in urine and saliva for rapid sports-related concussion diagnosis.
- To investigate the kinetics and clinical utility of these potential biomarkers.
- To support diagnostic, prognostic, and return-to-play decisions in athletes.
Main Methods:
- Prospective, multicentre cohort study during two Rugby Union seasons.
- Recruitment of professional rugby players from top English leagues.
- Collection of saliva and urine samples at multiple timepoints during the Head Injury Assessment (HIA) protocol and return-to-play process from injured and control athletes.
Main Results:
- This section is to be filled once the study results are available.
- The study is designed to analyze biomarker levels in relation to concussion events.
- Kinetics and correlation with clinical assessments will be evaluated.
Conclusions:
- This research seeks to establish objective, non-invasive biomarkers for concussion management.
- Successful identification of biomarkers could significantly improve athlete safety and care.
- Findings will inform clinical practice regarding concussion diagnosis and return-to-play protocols.
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