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Patient-reported gout attack frequency and allopurinol use in general practice in the Netherlands: a prospective

Kevin D B van Leeuwen1, Arthur M Bohnen1, Marloes L Jacobs1

  • 1Department of General Practice, Erasmus Medical Center, Rotterdam, The Netherlands.

BMJ Open
|November 28, 2018
PubMed

Insights

This study investigates gout attack frequency in Dutch general practice, assessing the impact of allopurinol treatment on reducing gout flares. Findings will clarify the clinical relevance of uric acid lowering therapy for gout management.

Area of Science:

  • Rheumatology
  • General Practice
  • Epidemiology

Background:

  • Gout is a prevalent inflammatory arthritis in Dutch general practice.
  • Long-term uric acid lowering treatment is common for gout management.
  • The effectiveness of this treatment in preventing gout attacks is not well-established.

Purpose of the Study:

  • To determine the frequency of self-reported gout attacks in patients diagnosed with gout.
  • To evaluate the effect of allopurinol use on the frequency of gout attacks in general practice.

Main Methods:

  • Prospective observational cohort study of adult gout patients in Dutch general practice.
  • Baseline and 2-year follow-up with questionnaires assessing gout attacks, medication, and lifestyle factors.
  • Propensity score matching and multilevel Poisson regression to analyze allopurinol's effect on gout attack frequency.

Main Results:

  • Data collection for NTR6329 is ongoing; pre-results are not yet available.
  • The study aims to provide corrected estimated effects of allopurinol on gout attack frequency.

Conclusions:

  • The study will clarify the clinical relevance of allopurinol in preventing gout attacks within the Dutch general practice setting.
  • Findings will inform treatment guidelines and improve gout management strategies.
Abstract

Keywords:
epidemiologygeneral medicine (see internal medicine)rheumatology

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