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Involvement of miRNA polymorphism in mucositis development in childhood acute lymphoblastic leukemia treatment

Ángela Gutierrez-Camino1,2, Maitane Umerez1, Elixabet Lopez-Lopez1,2

  • 1Department of Genetics, Physic Anthropology & Animal Physiology, University of the Basque Country, UPV/EHU, Leioa, 48940, Spain.

Pharmacogenomics
|November 28, 2018
PubMed
Abstract

Insights

Genetic variants in microRNAs (miRNAs) are associated with mucositis and other side effects in children undergoing acute lymphoblastic leukemia (ALL) therapy. These single nucleotide polymorphisms (SNPs) may influence drug response and toxicity.

Area of Science:

  • Genetics
  • Pediatric Oncology
  • Pharmacogenomics

Background:

  • Mucositis is a common side effect of chemotherapy for childhood acute lymphoblastic leukemia (ALL).
  • MicroRNAs (miRNAs) play a role in regulating genes involved in drug metabolism and response.
  • Single nucleotide polymorphisms (SNPs) in miRNAs could alter their function and impact treatment outcomes.

Purpose of the Study:

  • To investigate the association between miRNA genetic variants and the risk of developing mucositis in children with ALL.
  • To explore the potential role of miRNA SNPs in mediating chemotherapy-induced toxicities.

Main Methods:

  • Analysis of 160 SNPs in 179 Spanish children with B-cell precursor ALL.
  • Homogeneous treatment protocols (LAL/SHOP) were used.

Main Results:

  • Three SNPs in miR-4268, miR-4751, and miR-3117 were significantly associated with mucositis, diarrhea, and vomiting, respectively.
  • These findings suggest a genetic predisposition to specific chemotherapy side effects.

Conclusions:

  • Specific miRNA genetic variants may influence the development of mucositis, diarrhea, and vomiting during ALL therapy.
  • The identified SNPs could affect pharmacokinetic/pharmacodynamic pathways, explaining observed toxicities.
Keywords:
SNPacute lymphoblastic leukemiachemotherapymiRNAmucositis

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