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The GABA-Working Memory Relationship in Alzheimer's Disease
Pravat K Mandal1,2, Krity Kansara1, Aroma Dabas1
1Neuroimaging and Neurospectroscopy Laboratory, National Brain Research Centre, Gurgaon, India.
Journal of Alzheimer'S Disease Reports
|November 28, 2018
Summary
Alzheimer's disease (AD) is linked to altered levels of the neurotransmitter GABA. Research is exploring how GABA influences working memory deficits in AD patients.
Area of Science:
- Neuroscience
- Neurochemistry
Background:
- Alzheimer's disease (AD) is a progressive neurodegenerative disorder with no current cure.
- Abnormal levels of gamma-aminobutyric acid (GABA), the primary inhibitory neurotransmitter, are observed in key brain regions affected by AD.
- GABA levels are known to correlate with working memory capacity in healthy individuals.
Purpose of the Study:
- To investigate the role of GABA in the working memory impairments characteristic of Alzheimer's disease.
- To explore the potential of neuroimaging and signal processing for GABA profiling in AD.
Main Methods:
- Utilizing advanced neuroimaging techniques.
- Applying sophisticated signal processing tools for neurochemical profiling.
- Examining GABAergic system function in the context of AD.
Main Results:
- Emerging evidence suggests GABAergic system dysfunction in AD brains.
- GABA levels may be a predictive marker for working memory deficits in AD.
Conclusions:
- Understanding the GABA-WM relationship in AD is crucial for developing targeted therapies.
- Neuroimaging and signal processing offer promising avenues for AD research and potential interventions.