Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A Kucherenko, V Pampukha, K Romanchuk

    Tsitologiia I Genetika
    |November 28, 2018
    PubMed
    Summary
    This summary is machine-generated.

    The IFNL4 gene ss469415590 ΔG/ΔG genotype is linked to reduced treatment success in Ukrainian patients with chronic hepatitis C receiving PEG-interferon/ribavirin therapy.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The effects of incorporating sprouted barley in diets of high-yielding dairy cows on production, efficiency, and nutrient digestibility.

    Animal : an international journal of animal bioscience·2025
    Same author

    MODERN APPROACHES IN MANAGEMENT OF CHILDREN WITH CHRONIC HEPATITIS B IN REMISSION OF ACUTE LYMPHOBLASTIC LEUKEMIA.

    Georgian medical news·2021
    Same author

    PREDICTIVE VALUE OF SERUM IL-17A AND IP-10 FOR EVALUATION OF LIVER FIBROSIS PROGRESSION IN PATIENTS WITH HBV/HIV CO-INFECTION.

    Georgian medical news·2019
    Same author

    [PECULIARITIES OF THE PREVALENCE OF POLYMORPHISM (C-589T) OF THE IL-4 GENE AND ITS RELATIONSHIP WITH SERUM IL-4 LEVEL IN PATIENTS WITH ACUTE BRUCELLOSIS IN THE REPUBLIC OF AZERBAIJAN].

    Georgian medical news·2019
    Same author

    Seasonal exposure of carbon dioxide ice on the nucleus of comet 67P/Churyumov-Gerasimenko.

    Science (New York, N.Y.)·2016
    Same author

    Exposed water ice on the nucleus of comet 67P/Churyumov-Gerasimenko.

    Nature·2016
    Same journal

    TSitologiia i genetika·2018
    Same journal

    TSitologiia i genetika·2018
    Same journal

    TSitologiia i genetika·2018
    Same journal

    TSitologiia i genetika·2018
    Same journal

    TSitologiia i genetika·2018
    Same journal

    TSitologiia i genetika·2018
    See all related articles

    Area of Science:

    • Genetics
    • Hepatology
    • Virology

    Background:

    • Chronic hepatitis C remains a significant global health concern.
    • Interferon Lambda 4 (IFNL4) gene polymorphisms are implicated in hepatitis C virus (HCV) infection outcomes.
    • Predicting treatment response is crucial for optimizing patient management.

    Purpose of the Study:

    • To investigate the association between the IFNL4 gene ss469415590 polymorphism and treatment efficacy.
    • To evaluate the impact of this genetic marker on sustained virological response in Ukrainian patients undergoing PEG-interferon/ribavirin therapy.

    Main Methods:

    • A cohort of 92 treatment-naive Ukrainian patients with HCV genotype 1 mono-infection was studied.
    • Patients were categorized into groups based on virological response: sustained virological response (SVR) and non-SVR (late or absent response).

    Related Experiment Videos

  • Genotyping for the IFNL4 ss469415590 polymorphism was performed using amplification-refractory mutation system PCR on genomic DNA.

    • Main Results:

    • The ss469415590 ΔG/ΔG genotype was significantly associated with a poor virological response.
    • Patients with the ΔG/ΔG genotype had an odds ratio (OR) of 3.62 (95% CI: 1.12-11.67) for non-SVR.
    • This finding suggests a genetic predisposition to treatment failure in this patient group.

    Conclusions:

    • The IFNL4 ss469415590 polymorphism is a predictive marker for treatment outcomes in Ukrainian chronic hepatitis C patients.
    • The ΔG/ΔG genotype is linked to lower rates of sustained virological response to PEG-interferon/ribavirin.
    • Genetic profiling could aid in personalizing hepatitis C treatment strategies.