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Related Concept Videos

Desmosomes01:05

Desmosomes

The term desmosome derives from the Greek words "desmo" and "soma" meaning "adhesion bodies." This structure was first observed during the late 1800s and described as small, dense nodules in the epidermis. Desmosomes are button-like structures that help form an interlinked network of intermediate filaments across the cells. These junctions are  essential to hold cells together under mechanical stress and to maintain tissue integrity. Desmosomes are multi-protein complexes comprising desmosomal...
Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

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Updated: Jun 25, 2026

Isolated Hepatic Perfusion as a Treatment for Liver Metastases of Uveal Melanoma
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Isolated Hepatic Perfusion as a Treatment for Liver Metastases of Uveal Melanoma

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Desmoplastic melanoma.

Norman G Nicolson1, Dale Han2

  • 1Department of Surgery, Section of Surgical Oncology, Yale School of Medicine, New Haven, Connecticut.

Journal of Surgical Oncology
|November 28, 2018
PubMed
Summary
This summary is machine-generated.

Desmoplastic melanoma (DM) is a rare skin cancer with distinct pathology. This review covers its subtypes and management, highlighting unique treatment considerations compared to conventional melanoma.

Keywords:
desmoplastic melanomaoutcomesradiation therapysentinel lymph node biopsy (SLNB)surgery

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Area of Science:

  • Dermatology
  • Oncology
  • Pathology

Background:

  • Desmoplastic melanoma (DM) is a rare variant of cutaneous melanoma.
  • DM exhibits unique biological and pathological features distinct from conventional melanoma (non-DM).
  • Histologic subtypes (pure and mixed) of DM correlate with patient outcomes.

Purpose of the Study:

  • To provide a contemporary overview of desmoplastic melanoma.
  • To review the current literature on the management of DM.
  • To highlight unique considerations influencing DM treatment approaches.

Main Methods:

  • Literature review of desmoplastic melanoma.
  • Analysis of contemporary research on DM pathology and subtypes.
  • Synthesis of information on DM management strategies.

Main Results:

  • DM classification into pure and mixed subtypes impacts prognosis.
  • DM management shares similarities with non-DM but requires specific considerations.
  • Current literature provides a basis for understanding DM's unique aspects.

Conclusions:

  • Desmoplastic melanoma necessitates tailored management strategies.
  • Understanding DM subtypes is crucial for predicting outcomes.
  • Further research into DM-specific treatments is warranted.