Related Experiment Video
Updated: Feb 2, 2026

11:21
Robotic Ablation of Atrial Fibrillation
Published on: May 29, 2015
20.2K
Noninvasive mapping before surgical ablation for persistent, long-standing atrial fibrillation
Marek P Ehrlich1, Guenther Laufer1, Iuliana Coti1
1Department of Cardiac Surgery, University of Vienna, Vienna, Austria.
The Journal of Thoracic and Cardiovascular Surgery
|November 29, 2018
Summary
Noninvasive mapping revealed biatrial rotor and macro-reentry activity in all patients with persistent atrial fibrillation, guiding surgical ablation for improved outcomes.
Area of Science:
- Cardiology
- Electrophysiology
- Medical Devices
Background:
- Persistent and long-standing persistent atrial fibrillation (AF) present complex electrophysiological mechanisms.
- Surgical ablation, such as the Cox-Maze procedure, is a treatment option for AF, particularly in patients undergoing cardiac surgery.
Purpose of the Study:
- To investigate the electrophysiologic mechanisms of atrial fibrillation using noninvasive 3-dimensional mapping.
- To assess the utility of preoperative mapping in patients undergoing concomitant surgical ablation for AF.
Main Methods:
- A pilot trial involving 10 patients with persistent AF undergoing cardiac surgery.
- Preoperative mapping was performed using a noninvasive surface system (ECVUE).
- Surgical ablation included Cox-Maze III/IV procedure with cryoablation and radiofrequency, and left atrial appendage removal.
Main Results:
- Noninvasive mapping successfully identified AF mechanisms in all patients.
- Biatrial pathology was evident in all subjects.
- Rotor and macro-reentry activity were consistently observed, with rotor activity in the right atrium present in all patients.
Conclusions:
- This study demonstrates the feasibility of preoperative noninvasive mapping in surgical AF patients.
- The findings highlight the biatrial nature of AF mechanisms, supporting comprehensive ablation strategies.
- Preoperative mapping can enhance understanding of AF pathophysiology and personalize surgical ablation approaches.
More Related Videos
Related Concept Videos
Amyloid Fibrils
11.9K
Amyloid fibrils are aggregates of misfolded proteins. Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils.
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining,...
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining,...
11.9K
Amyloid Fibrils
6.4K
6.4K
Standing Waves
5.5K
Sometimes waves do not seem to move; rather, they just vibrate in place. Unmoving waves can be seen on the surface of a glass of milk kept in a refrigerator, which is one example of standing waves. Vibrations from the refrigerator motor create waves on the milk that oscillate up and down but do not seem to move across the surface. These waves are formed or created by the superposition of two or more identical moving waves in opposite directions. The waves move through each other, with their...
5.5K
Fibril-associated Collagen
3.4K
Fibril-associated collagens are a type of collagens present in the extracellular matrix with interrupted triple helices or FACIT (Fibril-associated collagens interrupted triple-helices). FACIT help connect and attach the collagen fibrils with each other as well as with other proteins of the extracellular matrix.
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
3.4K
Modes of Standing Waves - I
4.1K
A close look at earthquakes provides evidence for the conditions appropriate for resonance, standing waves, and constructive and destructive interference. A building may vibrate for several seconds with a driving frequency matching the building's natural frequency of vibration; this produces a resonance that results in one building collapsing while the neighboring buildings do not. Often, buildings of a certain height are devastated, while other taller buildings remain intact. This...
4.1K
Modes of Standing Waves: II
1.8K
The starting point for expressing the modes of standing waves is understanding the boundary conditions that the waves must follow. The boundary conditions are derived from the physical understanding of how the standing waves are sustained, that is, how the vibrating particles of the medium behave at the boundaries imposed on them.
For a tube open at one end and closed at the other filled with air, the modes are such that there is always an antinode at the open end and a node at the closed end....
For a tube open at one end and closed at the other filled with air, the modes are such that there is always an antinode at the open end and a node at the closed end....
1.8K

