Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Differentiation, cancer, and anticancer activity.

C Y Tzen1, D N Estervig, P Minoo

  • 1Section of Experimental Pathology, Mayo Clinic/Foundation, Rochester, MN 55905.

Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire
|June 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The need for a telemedicine strategy for Botswana? A scoping review and situational assessment.

BMC health services research·2020
Same author

Health needs and eHealth readiness assessment of health care organizations in Kabul and Bamyan, Afghanistan.

Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit·2012
Same author

Iron accumulation in human spleen in autoimmune thrombocytopenia and hereditary spherocytosis.

Bratislavske lekarske listy·2012
Same author

Characterization of rectal, proximal and distal colon cancers based on clinicopathological, molecular and protein profiles.

International journal of oncology·2010
Same author

Structural changes in membranes of synchronized cells demonstrated by freeze-cleavage.

Nature: New biology·2010
Same author

Effect of 17-alpha hydroxyprogesterone caproate on the production of tumor necrosis factor-alpha and the expression of cyclooxygenase-2 in lipopolysaccharide-treated gravid human myometrial explants.

Journal of perinatology : official journal of the California Perinatal Association·2010

Carcinogenesis involves defects in cell differentiation and proliferation control. Maintaining integrated regulation of these processes in stem cells can prevent cancer or revert transformed cells.

Area of Science:

  • Cellular biology
  • Cancer research
  • Developmental biology

Background:

  • Carcinogenesis is a multistep process driven by defects in cellular differentiation and proliferation control.
  • Mesenchymal stem cells (3T3 T) are crucial for understanding these regulatory mechanisms.

Purpose of the Study:

  • To investigate the distinct biological processes controlling differentiation and proliferation.
  • To identify defects in these regulatory processes linked to carcinogenesis.
  • To explore the potential of modulating these processes to prevent or reverse cancer.

Main Methods:

  • Utilized 3T3 T mesenchymal stem cells to model differentiation and proliferation control.
  • Analyzed defects in regulatory pathways associated with carcinogenesis.

Related Experiment Videos

  • Induced nonterminal differentiation in normal and transformed stem cells.

    • Main Results:

    • Established a distinct, integrally regulated sequence of biological processes governing differentiation and proliferation.
    • Identified specific defects in these regulatory processes as contributors to carcinogenesis, noting they involve altered regulatory stringency.
    • Demonstrated that inducing nonterminal differentiation can confer resistance to carcinogenesis or revert transformed cells.

    Conclusions:

    • The integral regulation of differentiation and proliferation is critical for maintaining cellular homeostasis.
    • Defects in this integrated regulation, rather than absolute failures, are implicated in carcinogenesis.
    • Modulating differentiation pathways offers a potential strategy for cancer prevention and therapy.