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Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA
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Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA

Published on: February 9, 2011

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Detection of methicillin-resistant Staphylococcus aureus (MRSA) in clinical samples of patients with external ocular

Ashkan Faridi1, Amir Tavakoli Kareshk2, Mehdi Fatahi-Bafghi3

  • 1Student Research Committee, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.

Iranian Journal of Microbiology
|November 29, 2018
PubMed
Abstract

Insights

Antibiotic resistance patterns and specific genes like mecA were identified in Staphylococcus aureus (S. aureus) from ocular infections. The study highlights the serious emergence of MRSA with SCCmec type IV and the pvl gene in patients.

Area of Science:

  • Ophthalmology
  • Microbiology
  • Genetics

Background:

  • Staphylococcus aureus is a primary cause of Gram-positive bacterial ocular infections.
  • Understanding antibiotic resistance and virulence factors in S. aureus is crucial for treating eye infections.

Purpose of the Study:

  • To investigate antibiotic resistance patterns in S. aureus isolates from ocular infections.
  • To detect specific resistance genes (ermA, ermB, ermC, msrA, mecA) and the pvl virulence gene.
  • To characterize Methicillin-Resistant Staphylococcus aureus (MRSA) isolates, including SCCmec typing.

Main Methods:

  • Collected 8 S. aureus isolates from 81 patients with eye damage.
  • Determined antibacterial susceptibility using the Kirby-Bauer disk diffusion method.
  • Detected resistance and virulence genes (ermA, ermB, ermC, msrA, mecA, pvl) via PCR; performed multiplex-PCR for SCCmec typing in MRSA isolates.

Main Results:

  • Three S. aureus isolates were identified as MRSA based on cefoxitin resistance.
  • The mecA gene was confirmed in all MRSA isolates.
  • One MRSA isolate, from a diabetic patient, harbored SCCmec type IV and the pvl gene.

Conclusions:

  • The presence of SCCmec type IV and the pvl gene in S. aureus from ocular infections is a significant concern.
  • Genetic characterization of MRSA isolates is vital for effective empirical therapy and infection control in ophthalmology.
  • Highlights the need for vigilance regarding emerging resistance mechanisms in ocular pathogens.
Keywords:
Eye infectionMRSAPanton–Valentine leukocidin

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