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Echovirus 30 and coxsackievirus A9 infection among young neonates with sepsis in Iran

Abdolnabi Shabani1, Manoochehr Makvandi1, Alireza Samarbafzadeh1

  • 1Infectious and Tropical Diseases Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Iranian Journal of Microbiology
|November 29, 2018
PubMed

Insights

Human enteroviruses (EV) caused 39% of sepsis cases in young infants in Ahvaz, Iran. Echovirus 30 was the most common strain, highlighting the need for viral diagnostics in neonatal sepsis.

Area of Science:

  • Virology
  • Neonatal Medicine
  • Infectious Diseases

Background:

  • Human enteroviruses (EV) are a leading cause of sepsis-like illness in neonates.
  • Previous studies have investigated EV serotypes in young infants, but their role in neonatal sepsis in Ahvaz, Iran, remained undetermined.

Purpose of the Study:

  • To determine the frequency of enteroviruses (EV) among hospitalized neonates presenting with clinical signs and symptoms of sepsis in Ahvaz, Iran.

Main Methods:

  • Blood samples were collected from 128 neonates with sepsis-like symptoms, all negative for bacterial culture.
  • RNA was extracted and tested for the 5'UTR of EV using RT-PCR, followed by VP1 region analysis for strain identification.
  • Sequencing of positive VP1 samples identified specific EV serotypes.

Main Results:

  • Enteroviruses (EV) were detected in 39.06% of the neonates studied.
  • Echovirus 30 was identified in 33.33% of positive samples, and Coxsackievirus A9 in 4.76%.

Conclusions:

  • This study reveals a high prevalence of EV, particularly Echovirus 30, in neonatal sepsis cases in Ahvaz.
  • These findings can guide the reduction of unnecessary antimicrobial use and hospitalizations.
  • This may represent one of the first reported enterovirus outbreaks in Ahvaz, Iran.
Abstract

Keywords:
CoxsackievirusEchovirusEnterovirusesSepsis

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