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Related Experiment Video

Updated: Feb 2, 2026

Fabrication of Zero Mode Waveguides for High Concentration Single Molecule Microscopy

Fabrication of Zero Mode Waveguides for High Concentration Single Molecule Microscopy

Published on: May 12, 2020

Porous Zero-Mode Waveguides for Picogram-Level DNA Capture.

Vivek Jadhav, David P Hoogerheide¹, Jonas Korlach²

¹Center for Neutron Research , National Institute of Standards and Technology , Gaithersburg , Maryland 20899 , United States.

|November 29, 2018

Summary

This summary is machine-generated.

Researchers developed wafer-scale porous waveguides for efficient DNA capture in single-molecule sequencing. This advancement significantly improves loading efficiency and reduces manufacturing costs for DNA sequencing applications.

Keywords:

Nanopore SMRT sequencing ZMWs nanofabrication porous membrane

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Area of Science:

Biotechnology
Nanotechnology
Genomics

Background:

Nanopore zero-mode waveguides enable picogram-level DNA capture for single-molecule sequencing.
Serial nanopore fabrication limits the scalability and cost-effectiveness of large waveguide arrays.

Purpose of the Study:

To develop a scalable and cost-effective method for fabricating waveguide arrays for DNA sequencing.
To enhance DNA capture efficiency compared to existing nanopore technologies.

Main Methods:

Wafer-scale fabrication of waveguide arrays on porous membranes using molecular-layer deposition.
Incorporation of serpentine pores at waveguide bases for efficient electrophoretic DNA capture.

Main Results:

Achieved wafer-scale fabrication of porous waveguide arrays.
Demonstrated loading efficiency up to 2 orders of magnitude greater than nanopore predecessors.
Enabled picogram-level DNA capture without serial pore milling.

Conclusions:

The developed porous zero-mode waveguides offer a scalable and cost-effective solution for DNA sequencing.
This technology significantly improves DNA loading efficiency for low-input applications.
Porous waveguides are suitable for single-molecule real-time sequencing applications benefiting from reduced input DNA.