Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Econometric Views (EViews)01:29

Econometric Views (EViews)

580
Econometric Views, often stylized as EViews, is a package that merges statistical analysis with econometric studies. It is designed to provide tools for time series analysis, forecasting, and econometric model simulation. The software originated from MicroTSP software and has evolved significantly since its inception in 1981. The history of EViews is marked by a continuous effort to enhance its computational speed and user interface. It was initially developed for large computing systems but...
580
Cranial Bones: Lateral View01:27

Cranial Bones: Lateral View

4.5K
The lateral view of the cranium is dominated by temporal, sphenoid, and ethmoid bones.
The temporal bone forms the lower lateral side of the skull. The temporal bone is subdivided into several regions. The flattened upper portion is the squamous portion of the temporal bone. Below this area and projecting anteriorly is the zygomatic process of the temporal bone, which forms the posterior portion of the zygomatic arch. Posteriorly is the mastoid portion of the temporal bone. Projecting...
4.5K
Revisionist Views of Adolescent and Adult Cognition01:24

Revisionist Views of Adolescent and Adult Cognition

310
A revisionist approach to Jean Piaget's theory of cognitive development has brought new insights that challenge and reinterpret his established ideas. Piaget proposed that the formal operational stage, emerging in adolescence, represents the culmination of cognitive maturity. During this stage, individuals are said to develop abstract thinking, engage in systematic problem-solving, and show a form of egocentrism, believing others are as preoccupied with their behavior as they are...
310
Molecular Models02:00

Molecular Models

43.7K
Physical models representing molecular architectures of chemical compounds play essential roles in understanding chemistry. The use of molecular models makes it easier to visualize the structures and shapes of atoms and molecules.
43.7K
Cranial Bones: Superior and Posterior View01:14

Cranial Bones: Superior and Posterior View

5.1K
The superior view of the cranium shows the frontal and paired parietal bones.
The frontal bone is the single bone that forms the forehead. At its anterior midline, between the eyebrows, there is a slight depression called the glabella. The frontal bone also forms the supraorbital margin of the orbit. Near the middle of this margin is the supraorbital foramen, the opening that provides passage for a sensory nerve to the forehead. The frontal bone is thickened just above each supraorbital margin,...
5.1K
Molecular Orbital Theory II03:51

Molecular Orbital Theory II

27.3K
Molecular Orbital Energy Diagrams
27.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Peripheral targets for neuropathic pain.

British journal of pharmacology·2026
Same author

Consensus and learning climate in temporary versus permanent teams in team-based learning.

Medical education online·2026
Same author

The analgesic potential of heavy water.

Nature biomedical engineering·2024
Same author

Human cold pain: a randomized crossover trial.

Pain·2024
Same author

Short-term cognitive learning outcomes in team-based learning: is the permanent team important?

Medical education online·2024
Same author

Human heat sensation: A randomized crossover trial.

Science advances·2024
Same journal

Comprehensive Analysis of Auditory Nerve Fiber Responses using Fiber-Specific Modeling.

Journal of neurophysiology·2026
Same journal

HCN channels modulate the medium afterhyperpolarization and adjust the firing gain of fast alpha motoneurons in mice.

Journal of neurophysiology·2026
Same journal

Targeting intracranial electrical stimulation to network regions defined within individuals causes network-level effects.

Journal of neurophysiology·2026
Same journal

When "Noise" Isn't Simply Noise: Deterministic Postural Drive During Noisy Galvanic Vestibular Stimulation (nGVS).

Journal of neurophysiology·2026
Same journal

Abrupt Scene Onsets and Gradually Emerging Scene Information Produce Distinct EEG Decoding Dynamics.

Journal of neurophysiology·2026
Same journal

From discovery to translation: charting a course for the <i>Journal of Neurophysiology</i>.

Journal of neurophysiology·2026
See all related articles

Related Experiment Video

Updated: Feb 2, 2026

A View of Their Own: Capturing the Egocentric View of Infants and Toddlers with Head-Mounted Cameras
03:56

A View of Their Own: Capturing the Egocentric View of Infants and Toddlers with Head-Mounted Cameras

Published on: October 5, 2018

8.0K

TRPA1: a molecular view.

Jannis E Meents1, Cosmin I Ciotu2, Michael J M Fischer2

  • 1Institute of Physiology, University Hospital RWTH Aachen , Aachen , Germany.

Journal of Neurophysiology
|November 29, 2018
PubMed
Summary
This summary is machine-generated.

The transient receptor potential ankyrin 1 (TRPA1) channel is crucial in pain and inflammation. This review summarizes TRPA1's structure and binding sites, aiding new drug development for pain relief.

Keywords:
TRPA1ion channelnociceptorpain

More Related Videos

Molecular Evolution of the Tre Recombinase
12:02

Molecular Evolution of the Tre Recombinase

Published on: May 29, 2008

10.1K
Detection and Quantification of Tunneling Nanotubes Using 3D Volume View Images
12:45

Detection and Quantification of Tunneling Nanotubes Using 3D Volume View Images

Published on: August 31, 2022

3.6K

Related Experiment Videos

Last Updated: Feb 2, 2026

A View of Their Own: Capturing the Egocentric View of Infants and Toddlers with Head-Mounted Cameras
03:56

A View of Their Own: Capturing the Egocentric View of Infants and Toddlers with Head-Mounted Cameras

Published on: October 5, 2018

8.0K
Molecular Evolution of the Tre Recombinase
12:02

Molecular Evolution of the Tre Recombinase

Published on: May 29, 2008

10.1K
Detection and Quantification of Tunneling Nanotubes Using 3D Volume View Images
12:45

Detection and Quantification of Tunneling Nanotubes Using 3D Volume View Images

Published on: August 31, 2022

3.6K

Area of Science:

  • Neuroscience
  • Pharmacology
  • Molecular Biology

Background:

  • The transient receptor potential ankyrin 1 (TRPA1) ion channel is expressed in pain-sensing neurons and other tissues.
  • TRPA1 is activated by numerous compounds, many causing pain and inflammation, making it a key pharmaceutical target.
  • TRPA1 plays a significant role in various pain conditions, as evidenced by studies in humans and animals.

Purpose of the Study:

  • To review the current knowledge on the TRPA1 channel.
  • To focus on the molecular structure of TRPA1.
  • To summarize known binding and gating sites of the TRPA1 channel.

Main Methods:

  • Literature review of published research on TRPA1.
  • Analysis of studies elucidating TRPA1's molecular structure.
  • Compilation of data on TRPA1 binding and modulatory sites.

Main Results:

  • TRPA1 is a validated target for anti-inflammatory and analgesic drug development.
  • Significant progress has been made in understanding TRPA1's molecular structure.
  • Numerous binding and gating sites on the TRPA1 channel have been identified.

Conclusions:

  • TRPA1 is a critical ion channel involved in pain and inflammation.
  • Understanding TRPA1's structure and sites is essential for developing targeted therapeutics.
  • This review provides a consolidated overview to navigate the growing body of TRPA1 research.