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Laparoscopic Anterior Right Hepatectomy: A Single-Center Experience
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Methotrexate Therapy for Ectopic Pregnancies: A Tertiary Center Experience
Ozgur Ozyuncu1, Atakan Tanacan1, Sinem Ayse Duru1
1Division of Perinatology, Department of Obstetrics and Gynecology, Faculty of Medicine at Hacettepe University, Ankara, Turkey.
Summary
Methotrexate (MTX) therapy is an effective treatment for ectopic pregnancy (EP), achieving a 68.5% success rate. Caution is advised for patients with higher hCG levels or advanced gestational weeks.
Area of Science:
- Reproductive Medicine
- Pharmacology
Background:
- Ectopic pregnancy (EP) poses significant risks to maternal health.
- Methotrexate (MTX) is a chemotherapeutic agent used in EP treatment.
Purpose of the Study:
- To evaluate the efficacy and outcomes of MTX therapy in a diverse cohort of EP cases.
- To identify factors influencing MTX treatment success in EP.
Main Methods:
- Retrospective analysis of 99 patients with various types of EP treated with MTX.
- Categorization of EPs included tubal, cesarean section scar, cervical, and pregnancies of unknown location (PUL).
Main Results:
- Overall MTX success rate was 68.5% for EP.
- Higher success rates observed in PUL (95%) and cervical/CS scar EPs (100%).
- Lower success rates correlated with higher hCG, advanced gestational age, fetal cardiac activity, and abdominal-pelvic pain.
Conclusions:
- MTX can be a primary treatment for EP under specific clinical conditions.
- Treatment protocols and patient selection require careful consideration of clinical and biochemical markers.
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