Related Experiment Video
Updated: Feb 2, 2026

Laparoscopic Anterior Right Hepatectomy: A Single-Center Experience
Published on: December 4, 2023
Methotrexate Therapy for Ectopic Pregnancies: A Tertiary Center Experience
Ozgur Ozyuncu1, Atakan Tanacan1, Sinem Ayse Duru1
1Division of Perinatology, Department of Obstetrics and Gynecology, Faculty of Medicine at Hacettepe University, Ankara, Turkey.
Objective:
Our aim is to demonstrate the importance of methotrexate (MTX) therapy for the treatment of ectopic pregnancy (EP).
Methods:
This retrospective study consisted of 99 patients (72 tubal EPs, 20 pregnancies of unknown location (PUL), 4 cesarean section (CS) scar EPs and 3 cervical EPs) treated with MTX.
Results:
Methotrexate therapy was successful in 68.5% of EPs. There were statistically significant differences between the MTX success and failure groups based on ultrasonographic findings, patient complaints, gestational week and serum human chorionic gonadotropin (hCG) values. The MTX success rates in PUL and tubal pregnancies were 95% and 61.1%, respectively. The MTX success rates in single-dose, two-dose and multi-dose protocol groups were 86.9%, 28.6% and 40%, respectively. All cervical and CS scar ectopic pregnancies were treated successfully with MTX therapy.
Conclusion:
Methotrexate might be the first-line treatment option for EPs under certain conditions. Physicians must be more cautious in cases with higher hCG values, the presence of abdominal-pelvic pain, the presence of fetal cardiac activity, larger gestational sac (GS) diameters, and more advanced gestational weeks according to the last menstrual period.
Related Concept Videos
Tertiary Healthcare System
Nomenclature of Secondary and Tertiary Amines
Lattice Centering and Coordination Number
Types of Unit Cells
Imagine taking a large number of identical...
Center of Gravity
Center of Gravity
To determine its location, the principle of moments can be utilized by dividing the object into...
Center of Mass
The knowledge of the center of mass can also help us to describe and predict the motion of objects. For example, when a ball is thrown...

