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Xenon handling in the liver: red cell capacity effect
C A Goresky1, A J Schwab, C P Rose
1McGill University Medical Clinic, Montreal General Hospital, Quebec, Canada.
Circulation Research
|October 1, 1988
Summary
Xenon preferentially binds to red blood cells, influencing its distribution in the liver. This study quantified xenon-tissue interaction, revealing its flow-limited distribution and estimating liver tissue partition coefficients.
Area of Science:
- Physiology
- Pharmacology
- Medical Imaging
Background:
- Xenon (Xe), despite being a noble gas, shows preferential association with red blood cells.
- Understanding xenon's interaction with liver tissue is crucial for its potential applications.
Purpose of the Study:
- To characterize the effect of red blood cell association on xenon distribution in the liver.
- To determine the nature of xenon-tissue interaction within the liver using multiple indicator dilution studies.
Main Methods:
- Multiple indicator dilution studies were performed in anesthetized dogs via portal vein injection and hepatic vein collection.
- Experiments were conducted at both normal and reduced hematocrit levels, using labeled red blood cells, sucrose, water, and xenon as indicators.
- Analysis of indicator dilution curves assessed xenon's distribution kinetics and tissue-plasma partition coefficient.
Main Results:
- Xenon distribution curves were influenced by hematocrit, appearing earlier and peaking higher at normal hematocrit compared to labeled water.
- At reduced hematocrit, xenon curves were delayed and diminished relative to water, indicating flow-limited distribution.
- The liver cell tissue-plasma xenon partition coefficient was estimated at 1.93 ml/ml liver space (1.79 ml/g).
Conclusions:
- Xenon undergoes flow-limited distribution in the liver, influenced by red blood cell binding.
- The study successfully estimated the liver tissue-plasma partition coefficient for xenon.
- Xenon downslopes are not suitable for estimating liver blood flow.