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Variability in quantitative diffusion-weighted MR imaging (DWI) across different scanners and imaging sites: is there

Frederic Carsten Schmeel1

  • 1Department of Radiology, University Hospital Bonn, Rheinische-Friedrich-Wilhelms-Universität Bonn, Sigmund-Freud-Straße 25, 53127, Bonn, Germany. Carsten.Schmeel@ukb.uni-bonn.de.

European Radiology
|November 30, 2018
PubMed
Abstract

Insights

Variability in apparent diffusion coefficient (ADC) measurements can be significant across MRI scanners. Standardizing diffusion-weighted imaging (DWI) protocols and focusing on ADC change can improve consistency in multi-center studies.

Area of Science:

  • Medical Imaging
  • Radiology
  • Diffusion-Weighted Imaging (DWI)

Background:

  • Apparent diffusion coefficient (ADC) measurements are crucial for quantitative MRI analysis.
  • Variability in ADC values across different MRI scanners and imaging sites presents a challenge for multi-center studies.

Discussion:

  • Substantial variability in ADC measurements necessitates addressing standardization issues.
  • Awareness of common error sources in DWI protocols is essential for reducing bias.
  • Absolute ADC values are less reliable than relative or normalized ADC values for consistent interpretation.

Key Insights:

  • ADC measurement variability is a significant concern in multi-center MRI studies.
  • Standardizing DWI protocols and site-specific quality control are vital.
  • Normalized ADC values and ADC change are more robust metrics than absolute ADC for multi-center applications.

Outlook:

  • Implementing standardized DWI protocols can enhance the reliability of ADC measurements.
  • Further research into bias reduction techniques for ADC quantification is warranted.
  • Normalized ADC values show promise for facilitating consistent clinical decision-making in multi-center trials.
Keywords:
DiffusionMagnetic resonance imagingMulti-center studiesReproducibility of results

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