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Updated: Feb 1, 2026
09:54
Fabrication of Refractive-index-matched Devices for Biomedical Microfluidics
Published on: September 10, 2018
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Fabrication of Glass Microfluidic Devices
Christopher T Culbertson1, Jay Sibbitts2, Kathleen Sellens2
1Department of Chemistry, Kansas State University, Manhattan, KS, USA. culbert@ksu.edu.
Methods in Molecular Biology (Clifton, N.J.)
|November 30, 2018
Summary
This guide details fabricating glass microfluidic devices. It covers essential steps from design and photolithography to etching and bonding for creating microscale systems.
Area of Science:
- Materials Science
- Engineering
- Microfluidics
Background:
- Microfluidic devices enable precise control and manipulation of fluids at the microscale.
- Glass is a preferred material for microfluidic devices due to its optical transparency, chemical inertness, and biocompatibility.
Purpose of the Study:
- To provide a comprehensive, step-by-step protocol for fabricating glass-based microfluidic devices.
- To outline the critical stages involved in creating functional microfluidic systems using glass substrates.
Main Methods:
- Device design and simulation.
- Photomask generation.
- Photolithography for pattern transfer.
- Channel etching techniques.
- High-temperature bonding for device sealing.
Main Results:
- Successfully fabricated functional glass microfluidic devices.
- Demonstrated the efficacy of the outlined fabrication procedures.
- Established a reproducible method for creating microchannels in glass.
Conclusions:
- The presented procedures offer a robust framework for glass microfluidic device fabrication.
- This methodology facilitates the development of advanced microfluidic applications.
- The step-by-step guide ensures accessibility for researchers in the field.
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