Related Experiment Video
Updated: Feb 1, 2026
07:22
Standardized Method for Measuring Collection Efficiency from Wipe-sampling of Trace Explosives
Published on: April 10, 2017
9.9K
CA125 measured during menstruation can be misleading.
D A Crosby1,2, L E Glover1, F Martyn1,2
1Merrion Fertility Clinic, 60 Mount Street, Dublin 2
Irish Medical Journal
|November 30, 2018
Summary
Cyclical variation in serum cancer antigen 125 (CA-125) levels is crucial for monitoring endometriosis. Levels significantly increase during menstruation, impacting disease status assessment.
Area of Science:
- Gynecology
- Reproductive Endocrinology
- Clinical Chemistry
Background:
- Endometriosis is a chronic inflammatory condition affecting women of reproductive age.
- Serum cancer antigen 125 (CA-125) is a biomarker often used in endometriosis management.
- Understanding CA-125 fluctuations is vital for accurate disease assessment.
Observation:
- Two endometriosis cases demonstrated significant cyclical variation in serum CA-125 levels.
- CA-125 levels were notably higher during menstruation compared to mid-cycle.
Findings:
- Serum CA-125 levels exhibit a dramatic increase during menstruation in women with endometriosis.
- This cyclical pattern is a key characteristic of CA-125 behavior in this condition.
Implications:
- Accurate interpretation of CA-125 requires consideration of the menstrual cycle phase.
- Timing of blood draws for CA-125 measurement is critical for reliable endometriosis monitoring.
- This highlights the need for standardized protocols in CA-125 assessment for endometriosis.
Related Concept Videos
02:16Measures of Central Tendency
21.1K
The "center" of a data set is also a way of describing location. The two most widely used measures of the "center" of the data are the mean (average) and the median. The words "mean" and "average" are often used interchangeably. The substitution of one word for the other is common practice. The technical term is "arithmetic mean" and "average" is technically a center location. However, in practice among non-statisticians,...
21.1K
03:38Measurement: Standard Units
79.8K
Every measurement provides three kinds of information: the size or magnitude of the measurement (a number), a standard of comparison for the measurement (a unit), and an indication of the uncertainty of the measurement. While the number and unit are explicitly represented when a quantity is written, the uncertainty is an aspect of the errors in the measurement results.
79.8K
03:09Measuring Reaction Rates
29.2K
Polarimetry finds application in chemical kinetics to measure the concentration and reaction kinetics of optically active substances during a chemical reaction. Optically active substances have the capability of rotating the plane of polarization of linearly polarized light passing through them—a feature called optical rotation. Optical activity is attributed to the molecular structure of substances. Normal monochromatic light is unpolarized and possesses oscillations of the electrical...
29.2K
03:34Uncertainty in Measurement: Significant Figures
81.8K
All the digits in a measurement, including the uncertain last digit, are called significant figures or significant digits. Note that zero may be a measured value; for example, if a scale that shows weight to the nearest pound reads “140,” then the 1 (hundreds), 4 (tens), and 0 (ones) are all significant (measured) values.
81.8K
03:02Measurement: Derived Units
55.4K
The International System of Units or SI system, by international agreement, has fixed measurement units for seven fundamental properties: length, mass, time, temperature, electric current, amount of substance, and luminosity. These are called the SI base units.
55.4K
01:27Units of Measurement
5.2K
Mechanical engineering is one of the oldest branches of engineering. It deals with designing, analyzing, and manufacturing machines and mechanical systems. To ensure precise and accurate calculations, units of measurement are used. They provide a standard system for expressing and comparing physical quantities.
There are various well-known historical measurement systems, such as the Babylonian system, the Roman system, the Egyptian system, the Olympian system, the British system, and the Indus...
There are various well-known historical measurement systems, such as the Babylonian system, the Roman system, the Egyptian system, the Olympian system, the British system, and the Indus...
5.2K