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Related Concept Videos

Insulin: Dosing Regimen and Adverse Effects01:16

Insulin: Dosing Regimen and Adverse Effects

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Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
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Drug Dosing in Renal Diseases: Dose Adjustments Based on Drug Clearance and Elimination Rate Constant01:25

Drug Dosing in Renal Diseases: Dose Adjustments Based on Drug Clearance and Elimination Rate Constant

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In patients with renal disease, dosage adjustments are necessary to maintain therapeutic plasma drug concentrations and prevent toxicity or subtherapeutic exposure. Renal impairment alters drug pharmacokinetics, especially in conditions like uremia, where changes such as prolonged elimination half-life and altered apparent volume of distribution can significantly affect drug disposition. These changes require careful modification of the dosing regimen to achieve the desired clinical...
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Dose Size and Dosing Frequency: Determination Methods01:21

Dose Size and Dosing Frequency: Determination Methods

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Determining the optimal dose size and dosing frequency in pharmacotherapy is crucial for achieving therapeutic effectiveness while minimizing adverse effects. This article explores the methodologies employed in determining these parameters, focusing on their significance and interplay to tailor dosing regimens.Dose Size: Dose size refers to the amount of a drug administered in a single dose. It is determined based on the drug's pharmacodynamics and pharmacokinetics properties and...
302
Determination of Multiple Dosing Parameters: Loading and Maintenance Doses01:25

Determination of Multiple Dosing Parameters: Loading and Maintenance Doses

237
A loading dose is an essential pharmacological strategy to rapidly achieve the target plasma drug concentration necessary for an immediate therapeutic effect. This approach is especially critical for drugs characterized by slow absorption or extended half-lives, where delaying therapeutic plasma levels could compromise treatment outcomes. By administering a loading dose, clinicians ensure a prompt onset of drug action, even for agents with complex pharmacokinetic profiles.Achieving steady-state...
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Rational Dosage Regimen: Maintenance Dose and Loading Dose01:24

Rational Dosage Regimen: Maintenance Dose and Loading Dose

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A rational dosage regimen considers a drug's pharmacokinetics, including its absorption, distribution, metabolism, and elimination from the body. By understanding these factors, the appropriate dosage can be determined, and the dosing schedule can be designed to achieve and maintain the desired therapeutic effect while minimizing adverse effects.
In most cases, drugs are administered repetitively or infused continuously to maintain a steady-state concentration in the body. At a steady...
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Dose-Response Relationship: Overview01:03

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Agonists can bind with and activate receptors, resulting in the formation of drug-receptor complexes. Once formed, these complexes catalyze many biochemical processes at the cellular level and subsequently induce a pharmacologic response. The degree of response is directly proportional to the fraction of activated receptors, which in turn, depends on the concentration of the drug at the receptor site as well as the sensitivity of the receptor. An increase in the administered dose contributes to...
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Minimal Erythema Dose MED Testing
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THE DOSE AND DOSE-RATE EFFECTIVENESS FACTOR (DDREF)

Richard Wakeford1, Tamara Azizova, Wolfgang Dörr

  • 1Committee 1 of the International Commission on Radiological Protection Committee 1 of the International Commission on Radiological Protection Task Group 91 of the International Commission on Radiological Protection Committee 1 of the International Commission on Radiological Protection Committee 1 of the International Commission on Radiological Protection Committee 1 of the International Commission on Radiological Protection Committee 1 of the International Commission on Radiological Protection Task Group 91 of the International Commission on Radiological Protection Committee 1 of the International Commission on Radiological Protection Committee 1 of the International Commission on Radiological Protection Task Group 91 of the International Commission on Radiological Protection Committee 1 of the International Commission on Radiological Protection Committee 1 of the International Commission on Radiological Protection Committee 1 of the International Commission on Radiological Protection Committee 1 of the International Commission on Radiological Protection Task Group 91 of the International Commission on Radiological Protection Committee 1 of the International Commission on Radiological Protection Committee 1 of the International Commission on Radiological Protection Task Group 91 of the International Commission on Radiological Protection Task Group 91 of the International Commission on Radiological Protection Task Group 91 of the International Commission on Radiological Protection Task Group 91 of the International Commission on Radiological Protection Task Group 91 of the International Commission on Radiological Protection Task Group 91 of the International Commission on Radiological Protection Task Group 91 of the International Commission on Radiological Protection Committee 1 of the International Commission on Radiological Protection Task Group 91 of the International Commission on Radiological Protection.

Health Physics
|November 30, 2018
PubMed
Summary

No abstract available in PubMed .

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