Related Experiment Video
Updated: Feb 1, 2026
08:22
Application of Optical Coherence Tomography to a Mouse Model of Retinopathy
Published on: January 12, 2022
5.2K
Vertical Hyperreflective Lesions on Optical Coherence Tomography in Vitreoretinal Lymphoma
Gábor Gy Deák1,2, Debra A Goldstein1, Mei Zhou1
1Feinberg School of Medicine, Department of Ophthalmology, Northwestern University, Chicago, Illinois.
JAMA Ophthalmology
|November 30, 2018
Summary
Vertical hyperreflective lesions on optical coherence tomography (OCT) are a common finding in vitreoretinal lymphoma. These lesions often appear before other symptoms and typically resolve with treatment.
Area of Science:
- Ophthalmology
- Oncology
- Medical Imaging
Background:
- Vitreoretinal lymphoma presents diagnostic challenges due to unclear pathophysiology.
- Early detection and accurate imaging are crucial for managing intraocular lymphoma.
Purpose of the Study:
- To describe a specific imaging finding on optical coherence tomography (OCT) in patients diagnosed with vitreoretinal lymphoma.
- To correlate OCT findings with clinical presentation and treatment response.
Main Methods:
- Retrospective case series review of patients diagnosed with vitreoretinal lymphoma between July 2014 and January 2016.
- Analysis of optical coherence tomography (OCT) scans to identify characteristic lesions.
- Correlation of imaging findings with patient demographics, lymphoma subtype, and treatment outcomes.
Main Results:
- Seven patients (12 eyes) with intraocular lymphoma were identified.
- Vertical hyperreflective lesions affecting all neuroretinal layers were observed in 5 patients (58.3% of eyes).
- These lesions often preceded subretinal pigment epithelial deposits and localized around retinal vessels, resolving with minimal scarring after chemotherapy.
Conclusions:
- Vertical hyperreflective lesions are a common and significant finding on OCT in eyes with vitreoretinal lymphoma.
- OCT imaging can aid in the early diagnosis and monitoring of vitreoretinal lymphoma.
- The characteristic lesions identified may offer insights into the pathophysiology of vitreoretinal lymphoma.
Related Concept Videos
01:23Vertical Curve: Problem Solving
493
Vertical curves provide the transition between two roadway grades, ensuring safety, comfort, and functionality. Calculating elevations at specific stations along the curve involves several systematic steps based on the curve's geometry and provided design parameters.The vertical curve is defined by its length, grades, Point of Vertical Intersection (P.V.I.) location, and P.V.I. elevation. The stations of the Point of Vertical Curvature (P.V.C.), where the curve begins, and the Point of Vertical...
493
01:24Introduction to Vertical Curves
594
Vertical curves are parabolic transitions that connect different grades on highways and railroads, ensuring a smooth alignment between back and forward tangents. The back tangent represents the initial grade, while the forward tangent defines the subsequent grade. These curves can be symmetrical, with equal tangent lengths, or nonsymmetrical, with varying lengths. The key points defining a vertical curve include the Point of Vertical Intersection (P.V.I.), where the tangents meet; the Point of...
594
01:20Elevation of Intermediate Points on Vertical Curves
295
Vertical curves are essential in roadway design because they provide smooth transitions between varying roadway grades. Designing vertical curves involves calculating intermediate elevations and identifying the curve's highest or lowest point, which is essential for optimal roadway performance.Intermediate elevations on a vertical curve are determined using the tangent offset method. This method considers the initial elevation at the start of the curve, the grades, and the curve's geometry. The...
295
01:29Sight Distance in a Vertical Curve
389
Sight distance on vertical curves is critical in roadway design. It ensures drivers can see far enough ahead to identify and respond to hazards effectively. This directly impacts safety, driver comfort, and the overall efficiency of the transportation network.Vertical curves are classified into crest and sag curves based on their geometry. For crest curves, sight distance is determined by the line of sight between a driver's eye and a small object on the road's surface. Design parameters for...
389
01:10Computed Tomography
8.3K
Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
8.3K
01:29Positron Emission Tomography
7.2K
Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
7.2K