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Fluorescent voltage-sensitive dyes: applications for neurophysiology.

R M Dasheiff1

  • 1University of Pittsburgh Epilepsy Center, Pennsylvania 15213.

Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society
|July 1, 1988
PubMed
Summary
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Voltage-sensitive dyes optically monitor membrane potential changes in biological systems. This review covers their history, voltage sensitivity, techniques, limitations, and diverse applications, especially in neurophysiology.

Area of Science:

  • Biophysics
  • Neuroscience
  • Cell Biology

Background:

  • Voltage-sensitive dyes offer optical monitoring of membrane potential.
  • Their use has expanded due to advancements in dye development over two decades.
  • These dyes provide insights into biological systems from bacteria to primate brain function.

Purpose of the Study:

  • To review the history and development of voltage-sensitive dyes.
  • To present data supporting their voltage sensitivity and required techniques.
  • To comprehensively discuss limitations and diverse research applications, particularly in neurophysiology.

Main Methods:

  • Historical review of voltage-sensitive dye development.
  • Analysis of data supporting dye voltage sensitivity.

Related Experiment Videos

  • Description of techniques for dye application and interpretation.
  • Compilation of diverse research applications.

    • Main Results:

    • Voltage-sensitive dyes have a long history of development.
    • Current dyes offer reliable optical monitoring of membrane potential.
    • Applications span various biological systems, including complex neural networks.

    Conclusions:

    • Voltage-sensitive dyes are valuable tools for studying membrane potential.
    • Understanding their limitations is crucial for accurate interpretation.
    • Their applications continue to expand across numerous research fields, especially neurophysiology.