Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cooperative Binding of Transcription Regulators02:13

Cooperative Binding of Transcription Regulators

7.3K
Transcriptional regulators bind to specific cis-regulatory sequences in the DNA to regulate gene transcription. These cis-regulatory sequences are very short, usually less than ten nucleotide pairs in length. The short length means that there is a high probability of the exact same sequence randomly occurring throughout the genome.  Since regulators can also bind to groups of similar sequences, this further increases the chances of random binding. Transcriptional regulators form...
7.3K
Enzyme-linked Receptors01:00

Enzyme-linked Receptors

86.6K
Enzyme-linked receptors are proteins that act as both receptor and enzyme, activating multiple intracellular signals. This is a large group of receptors that include the receptor tyrosine kinase (RTK) family. Many growth factors and hormones bind to and activate the RTKs.
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...
86.6K
The Nucleosome Core Particle02:10

The Nucleosome Core Particle

14.4K
Nucleosomes are the DNA-histone complex, where the DNA strand is wound around the histone core. The histone core is an octamer containing two copies of H2A, H2B, H3, and H4 histone proteins.
The paradox
Nucleosomes, paradoxically, perform two opposite functions simultaneously. On the one hand, their main responsibility is to protect the delicate DNA strands from physical damage and help achieve a higher compaction ratio. While on the other hand, they must allow polymerase enzymes to access DNA...
14.4K
Inheritance of Chromatin Structures03:17

Inheritance of Chromatin Structures

7.5K
Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying...
7.5K
Protein-protein Interfaces02:04

Protein-protein Interfaces

14.7K
Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
14.7K
Internal Receptors01:31

Internal Receptors

74.7K
Many cellular signals are hydrophilic and therefore cannot pass through the plasma membrane. However, small or hydrophobic signaling molecules can cross the hydrophobic core of the plasma membrane and bind to internal, or intracellular, receptors that reside within the cell. Many mammalian steroid hormones use this mechanism of cell signaling, as does nitric oxide (NO) gas.
74.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Insect Antifeedant Benzofurans from <i>Pericallis</i> Species.

Molecules (Basel, Switzerland)·2023
Same author

Proposal for structural revision of several disubstituted tricycloalternarenes.

Phytochemistry·2022
Same author

Proposal for structural revision of several monosubstituted tricycloalternarenes.

Phytochemistry·2022
Same author

Sesquiterpene Lactones from <i>Artemisia absinthium</i>. Biotransformation and Rearrangement of the Insect Antifeedant 3α-hydroxypelenolide.

Plants (Basel, Switzerland)·2021
Same author

Alkane-, alkene-, alkyne-γ-lactones and ryanodane diterpenes from aeroponically grown Persea indica roots.

Phytochemistry·2020
Same author

Studies on the sesquiterpene lactones from Laurus novocanariensis lead to the clarification of the structures of 1-epi-tatridin B and its epimer tatridin B.

Phytochemistry·2018
Same journal

Augmentation of Docetaxel-Induced Cytotoxicity in Human PC-3 Androgen-Independent Prostate Cancer Cells by Combination With Four Natural Apoptosis-Inducing Anticancer Compounds.

Natural product communications·2023
Same journal

Indirubin Inhibits TRAIL-Induced Activation of Death Receptor 5 in Jurkat Cells.

Natural product communications·2023
Same journal

Phytochemical characterization and bioactivity toward breast cancer cells of unhydrolyzed and acid-hydrolyzed extracts of <i>Fagonia indica</i>.

Natural product communications·2022
Same journal

PQQ Supplementation and SARS-CoV-2 Spike Protein-Induced Heart Inflammation.

Natural product communications·2022
Same journal

Prediction the Molecular Mechanism of Shengmai Injection in Acute Treatment of COVID-19 Based on Network Pharmacology.

Natural product communications·2022
Same journal

<i>Oroxylum indicum</i> extract, at a physiologically relevant dosage, does not induce hepatotoxicity in C57BL/6J mice.

Natural product communications·2021
See all related articles

Related Experiment Video

Updated: Feb 1, 2026

Chemical Dimerization-Induced Protein Condensates on Telomeres
08:52

Chemical Dimerization-Induced Protein Condensates on Telomeres

Published on: April 12, 2021

3.7K

The Dimerization of Precocene I.

Braulio M Fraga, Inmaculada Cabrera

    Natural Product Communications
    |November 30, 2018
    PubMed
    Summary
    This summary is machine-generated.

    Bromination of precocene I prevents oligomerization, yielding a dimer. This dimer can be obtained via reduction, offering a controlled synthesis pathway for precocene derivatives.

    More Related Videos

    Isolating Free Carbenes, their Mixed Dimers and Organic Radicals
    10:44

    Isolating Free Carbenes, their Mixed Dimers and Organic Radicals

    Published on: April 19, 2019

    11.6K
    Native Polyacrylamide Gel Electrophoresis Immunoblot Analysis of Endogenous IRF5 Dimerization
    08:57

    Native Polyacrylamide Gel Electrophoresis Immunoblot Analysis of Endogenous IRF5 Dimerization

    Published on: October 6, 2019

    10.7K

    Related Experiment Videos

    Last Updated: Feb 1, 2026

    Chemical Dimerization-Induced Protein Condensates on Telomeres
    08:52

    Chemical Dimerization-Induced Protein Condensates on Telomeres

    Published on: April 12, 2021

    3.7K
    Isolating Free Carbenes, their Mixed Dimers and Organic Radicals
    10:44

    Isolating Free Carbenes, their Mixed Dimers and Organic Radicals

    Published on: April 19, 2019

    11.6K
    Native Polyacrylamide Gel Electrophoresis Immunoblot Analysis of Endogenous IRF5 Dimerization
    08:57

    Native Polyacrylamide Gel Electrophoresis Immunoblot Analysis of Endogenous IRF5 Dimerization

    Published on: October 6, 2019

    10.7K

    Area of Science:

    • Organic Chemistry
    • Synthetic Chemistry

    Background:

    • Previous studies showed precocene I oligomerizes with Brønsted and Lewis acids.
    • Oligomerization leads to a mixture of dimers, trimers, and tetramers.

    Purpose of the Study:

    • To develop a method to block precocene I oligomerization.
    • To synthesize a specific precocene I dimer controllably.
    • To explore oxidation reactions of precocene I.

    Main Methods:

    • Bromination of precocene I using phenyltrimethylammonium tribromide (PTT).
    • Reduction of the dibromo-dimer with tri-n-butyl tin hydride.
    • Oxidation of precocene I with Jones reagent.

    Main Results:

    • Bromination with PTT successfully blocked oligomerization, yielding a dibromo-dimer.
    • Reduction of the dibromo-dimer afforded the same dimer previously obtained through acid-catalyzed reactions.
    • Oxidation resulted in 3-hydroxy-4-chromanone, 3,4-chromandione, 3,4-diacid, and two dimers.

    Conclusions:

    • Phenyltrimethylammonium tribromide is effective in preventing precocene I oligomerization.
    • A controlled synthesis of a specific precocene I dimer is achievable.
    • Jones oxidation provides access to various functionalized precocene derivatives and dimers.