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Impact of genetic polymorphisms on platelet function and response to anti platelet drugs

Teresa Strisciuglio1, Danilo Franco1, Giuseppe Di Gioia1

  • 1Division of Cardiology, Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy.

Cardiovascular Diagnosis and Therapy
|December 1, 2018
PubMed

Insights

Cardiovascular genomics identifies genes influencing coronary artery disease (CAD) susceptibility. Understanding genetic variations in platelet function and anti-platelet drug response is crucial for treating CAD patients.

Area of Science:

  • Cardiovascular genomics
  • Platelet biology
  • Pharmacogenomics

Background:

  • Coronary artery disease (CAD) susceptibility is linked to polymorphic genes.
  • Platelet activation, aggregation, and drug response exhibit heritable variability.
  • Genetic factors influence CAD risk and treatment outcomes, especially after percutaneous coronary intervention (PCI).

Purpose of the Study:

  • To explore the role of cardiovascular genomics in identifying genes associated with CAD.
  • To investigate the genetic basis of platelet hyper-reactivity and response to anti-platelet therapies.
  • To highlight the shift towards advanced genetic analysis techniques in CAD research.

Main Methods:

  • Identification of polymorphic genes related to cardiovascular disease.
  • Analysis of genes involved in platelet function and response to anti-platelet drugs.
  • Application of advanced genetic techniques including genome-wide association (GWAS) studies and miRNA-mRNA expression profiling.

Main Results:

  • Genes influencing platelet activation and aggregation are key in CAD predisposition.
  • Heritable hyper-reactivity of platelets affects drug response.
  • Advanced genomic techniques offer new insights into CAD genetics.

Conclusions:

  • Cardiovascular genomics is essential for understanding CAD susceptibility.
  • Genetic insights into platelet function and drug response can personalize CAD treatment.
  • Genome-wide association studies and expression profiling are advancing the field.

Keywords:
Genetic polymorphismhigh on treatment platelet reactivityplatelets function

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