Related Experiment Video
Updated: Feb 1, 2026

Author Spotlight: Advancements and Challenges in Surgical Treatments for Postamputation Pain
Published on: March 8, 2024
Using laxatives and/or enemas to accelerate the diagnosis in children presenting with acute abdominal pain: a
Marjolijn E W Timmerman1, Monika Trzpis2, Paul M A Broens1,2
1Division of Pediatric Surgery, Department of Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Insights
This study investigates if laxatives and enemas can help diagnose acute abdominal pain in children, potentially speeding up treatment for constipation and reducing emergency department visits.
Area of Science:
- Pediatric emergency medicine
- Gastroenterology
Background:
- Acute abdominal pain in children often mimics appendicitis, leading to misdiagnosis of constipation.
- Differentiating constipation from appendicitis is challenging due to similar symptoms and lack of clear diagnostic criteria.
- Missed constipation diagnoses result in repeated emergency department visits.
Purpose of the Study:
- To improve the diagnostic process for acute abdominal pain in children.
- To accelerate adequate treatment for constipation by supporting fecal evacuation.
- To reduce the need for repeated emergency department consultations.
Main Methods:
- An unblinded randomized controlled trial involving children aged 5-18 with acute abdominal pain and suspected appendicitis.
- Children requiring a second consultation after initial assessment were randomized.
- Intervention group received laxatives/enemas; control group received no medication.
Main Results:
- Primary outcome: differences in abdominal pain scores (FACES, VAS) at consultations.
- Secondary outcome: number of consultations needed for final diagnosis.
- Laxatives and enemas are safe and effective for pediatric constipation.
Conclusions:
- Supporting fecal evacuation may improve diagnosis and treatment of constipation in children with acute abdominal pain.
- This approach could potentially reduce healthcare utilization for undiagnosed constipation.
- Further research is needed to validate these findings and establish definitive diagnostic guidelines.
Introduction:
Many children with acute abdominal pain and suspicion of appendicitis are diagnosed with constipation. Nevertheless, it can be difficult to differentiate between acute constipation and acute appendicitis because of similar symptoms and lack of diagnostic criteria. Consequently, constipation is often missed despite repeated consultations at the emergency department. We hypothesise that the diagnostic process can be improved and adequate treatment accelerated by supporting faecal evacuation in children with acute abdominal pain.
Methods And Analysis:
An unblinded randomised controlled trial including children aged between 5 years and 18 years with acute abdominal pain and suspicion of acute appendicitis. Children who do not have a definitive diagnosis after the first consultation and who need to return for a second consultation will be randomised. The intervention group will receive laxatives and enemas, while the control group will receive no medication. If, after the second consultation, still no diagnosis is established, and a third consultation is needed, then the intervention group will receive only laxatives, and the control group will again not receive medication. The primary outcome will be the differences in abdominal pain scores obtained with FACES Pain Rating Scale and the visual analogue scale at first, second and possibly third consultation. The secondary outcome will be the number of consultations needed to reach final diagnosis.
Ethics And Dissemination:
Laxatives and enemas have proven to be safe and effective treatments for constipation in children. Adverse events are therefore not expected, however, should they occur, then the child concerned shall be properly followed and treated until the event is over. The local Medical Research Ethics Committee approved of this study and waived the otherwise mandatory insurance for human test subjects.
Trial Registration Numbers:
Pre-results: CCMO NL44710.042.12 andEudraCT 2013-000498-56.
Related Concept Videos
Drugs Affecting GI Tract Motility: Other Laxatives
Osmotic or saline laxatives, like magnesium hydroxide or milk of...
Lower GI Series: Barium Enema
Procedure Details
The examination begins by inserting a lubricated rectal tube into the patient's rectum to administer a radiopaque barium solution. The barium flow is carefully...
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Accelerators
The effectiveness of calcium chloride can...
Clinical Trials: Overview
Trial and Error and Algorithm

