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Optimized Griess Reaction for UV-Vis and Naked-eye Determination of Anti-malarial Primaquine
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Ionophores as Potent Anti-malarials: A Miracle in the Making
Hina Bharti1, Aakriti Singal1, Mohsin Raza1
1Department of Biochemistry, University of Delhi South Campus, Benito Juarez Road, New Delhi-110021, India.
Current Topics in Medicinal Chemistry
|December 1, 2018
Summary
Ionophores, drugs used for coccidiosis, show promise in treating malaria by disrupting parasite ionic balance. Repurposing these compounds may offer a new strategy against drug-resistant malaria parasites.
Area of Science:
- Parasitology
- Molecular Biology
- Drug Discovery
Background:
- Plasmodium parasites rely on precise ionic transport for survival, invasion, and transmission.
- Maintaining ionic homeostasis is critical for parasite pathogenesis.
- Drug resistance in malaria necessitates novel therapeutic strategies.
Purpose of the Study:
- To review the literature on ionophores as potential antimalarial agents.
- To explore the mechanisms by which ionophores affect Plasmodium parasites.
- To assess the prospects of ionophores in combating drug-resistant malaria.
Main Methods:
- Literature review of studies on ionophores and malaria.
- Analysis of ionophore mechanisms of action against Plasmodium.
- Evaluation of ionophores in experimental malaria models.
Main Results:
- Ionophores facilitate ionic transport across parasite membranes.
- Compounds like Monensin, Maduramicin, and Valinomycin show antimalarial activity.
- Ionophores can target multiple stages of the Plasmodium life cycle.
Conclusions:
- Ionophores represent a promising class of compounds for malaria treatment.
- Repurposing ionophores offers a cost-effective alternative to de novo drug development.
- Ionophores may help overcome existing drug resistance challenges in malaria.
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