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A Mouse Model to Evaluate the Long-Term Structural and Functional Outcomes after the Reversal of Prolonged Unilateral Ureteric Obstruction
Published on: July 18, 2025
Outcome and complications in goats treated by perineal urethrostomy for obstructive urolithiasis: 25 cases
Rachel E Oman1, Emily J Reppert2, Robert N Streeter3
1Department of Veterinary Medicine and Surgery, University of Missouri College of Veterinary Medicine, Columbia, Missouri.
Background:
Obstructive urolithiasis commonly affects male goats. Perineal urethrostomy (PU) can be a permanent treatment option but is generally considered undesirable because of the risk of stricture of the urethral stoma. Limited information exists regarding long-term outcome and complications in goats undergoing PU for treatment of obstructive urolithiasis.
Objectives:
To determine short-term and long-term outcome and complications in goats undergoing PU for treatment of obstructive urolithiasis.
Animals:
Twenty-five client-owned goats.
Methods:
Multi-institutional retrospective case series.
Results:
Of the 25 goats, 13 (52%) were alive at the time of follow-up. Mean time from surgery to follow-up was 34 months (range, 4-65). Nine goats (36%) died between discharge and follow-up with a mean survival time of 46 days (range, 5-120). Cause of death in 7 of 9 (78%) goats was related to urolithiasis. Goats treated by use of a modified proximal perineal urethrostomy (MPPU) were significantly more likely to survive at least 150 days postoperatively (P < .01). The most common postoperative complications were hemorrhage (10/25 [40%]) and surgical site infection (3/25 [12%]). Hemorrhage was significantly associated with MPPU (P < .0001). Stricture of the surgical stoma occurred in 7 of 22 (32%) discharged goats. Mean time to stricture was 65 days (range, 10-240).
Conclusions And Clinical Importance:
Perineal urethrostomy can provide effective long-term resolution of obstructive urolithiasis in goats. Re-obstruction or stricture seems most likely within the 1st 2 months after surgery. MPPU may provide better long-term results but should be approached cautiously because it can be associated with life-threatening hemorrhage.
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