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Updated: Feb 1, 2026

Mechanisms Underlying Gut Hormone Secretion Using the Isolated Perfused Rat Small Intestine
Published on: February 26, 2019
Secretin: An Old Hormone with a Burning Secret
Randall L Mynatt1, Eric Ravussin1
1Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA.
Abstract:
Most theories of meal-induced thermogenesis involve a gut-brain-brown adipose tissue axis driving sympathetic nervous system-mediated thermogenesis. Li et al. demonstrate that secretin released by the gut after a meal binds to abundant receptors in brown adipose tissue to stimulate thermogenesis, inhibiting food intake and thereby suggesting a novel role for secretin regulating satiety.
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