Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of Exosomes01:36

Overview of Exosomes

3.7K
Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
3.7K
Appendicitis-II: Diagnostic Studies and Management01:29

Appendicitis-II: Diagnostic Studies and Management

572
Diagnosing and managing appendicitis requires a structured and comprehensive approach that spans from initial assessment to postoperative care. Here is an overview of the process:
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...
572
Myasthenia Gravis: Diagnostic Tests01:15

Myasthenia Gravis: Diagnostic Tests

2.5K
Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
2.5K
Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

3.2K
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
3.2K
Non-ohmic Devices00:51

Non-ohmic Devices

1.5K
In most substances, the current flow is proportional to the voltage applied to it. A simple relationship between the values of current, voltage, and resistance is known as Ohm's law. Nonohmic devices do not exhibit a linear relationship between voltage and current. One such device is the semiconducting circuit element known as a diode. A diode is a circuit device that allows current flow in only one direction.
Consider a simple circuit consisting of a battery, a diode, and a resistor. A...
1.5K
Mnemonic Devices01:23

Mnemonic Devices

434
Mnemonic devices are cognitive tools that facilitate memory retention by linking new information to familiar patterns or organizational strategies. These techniques are beneficial for remembering complex or lengthy sets of information by simplifying and structuring them in easily retrievable ways.
Acronyms
Acronyms are created by using the initial letters of a series of words to form a new word or phrase. This approach condenses complex information into a single, memorable entity. For example,...
434

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Current management of impingement syndrome and repairable rotator cuff tears in South Korea: A web-based survey.

Asia-Pacific journal of sports medicine, arthroscopy, rehabilitation and technology·2026
Same author

A Nationwide Study on Pretransfusion Testing for 10 Years in Korea Using Health Insurance Review and Assessment Claims Data.

Journal of Korean medical science·2026
Same author

Follow-up Strategies in Metabolic and Bariatric Surgery: Current strategies and Challenges.

Journal of metabolic and bariatric surgery·2026
Same author

Outcomes and retear rates after subacromial and glenohumeral injection of a chitosan-based thermosensitive anti-adhesive agent during arthroscopic rotator cuff repair: a propensity score-matched analysis.

Clinics in shoulder and elbow·2026
Same author

Synergistic bone regeneration through sequential dual-drug delivery.

Biomedical engineering letters·2026
Same author

AI in Atomic Force Microscopy: Advancing Biological Nanoscale Imaging and Autonomous Discovery.

ACS nano·2026
Same journal

Correction: Kang et al. Fluid Flow to Electricity: Capturing Flow-Induced Vibrations with Micro-Electromechanical-System-Based Piezoelectric Energy Harvester. <i>Micromachines</i> 2024, <i>15</i>, 581.

Micromachines·2026
Same journal

Femtosecond Laser Texturing of Wood Coatings with Bio-Based Epoxy and Wax Additives for Enhanced Hydrophobicity.

Micromachines·2026
Same journal

Engineering of Optoelectronic Devices for Renewable Energy Applications.

Micromachines·2026
Same journal

Phase Transformation and Electrochemical Behavior of Hexagonal TiO<sub>2</sub> Nanotubes Under Different Annealing Temperatures and Heating Rates.

Micromachines·2026
Same journal

Process Optimization and Predictive Modeling of Femtosecond Laser Precision Milling for Commercial PMMA Slices.

Micromachines·2026
Same journal

A Hybrid Preprocessing Multi-Objective Surrogate Model for Thermal MEMS Actuators.

Micromachines·2026
See all related articles

Related Experiment Video

Updated: Feb 1, 2026

Tear-Derived Exosomal miR-15a as New Diagnostic Tool for Diabetic Retinopathy
07:45

Tear-Derived Exosomal miR-15a as New Diagnostic Tool for Diabetic Retinopathy

Published on: December 30, 2025

383

Toward Exosome-Based Neuronal Diagnostic Devices.

Yong Kyoung Yoo1, Junwoo Lee2, Hyungsuk Kim3

  • 1Department of Electrical Engineering, Kwangwoon University, 447-1 Wolgye, Nowon, Seoul 01897, Korea. yongkyoung0108@gmail.com.

Micromachines
|December 2, 2018
PubMed
Summary
This summary is machine-generated.

Exosomes show promise for diagnosing neurodegenerative diseases like Alzheimer's disease (AD). This review highlights exosome isolation and quantification methods for improved diagnostic accuracy, moving beyond current limitations.

Keywords:
Alzheimer’s diseaseParkinson’s diseasediagnosticsexosome

More Related Videos

Paper-Based Preconcentration and Isolation of Microvesicles and Exosomes
05:26

Paper-Based Preconcentration and Isolation of Microvesicles and Exosomes

Published on: April 29, 2020

6.7K
Formulating and Characterizing an Exosome-based Dopamine Carrier System
06:08

Formulating and Characterizing an Exosome-based Dopamine Carrier System

Published on: April 4, 2022

3.7K

Related Experiment Videos

Last Updated: Feb 1, 2026

Tear-Derived Exosomal miR-15a as New Diagnostic Tool for Diabetic Retinopathy
07:45

Tear-Derived Exosomal miR-15a as New Diagnostic Tool for Diabetic Retinopathy

Published on: December 30, 2025

383
Paper-Based Preconcentration and Isolation of Microvesicles and Exosomes
05:26

Paper-Based Preconcentration and Isolation of Microvesicles and Exosomes

Published on: April 29, 2020

6.7K
Formulating and Characterizing an Exosome-based Dopamine Carrier System
06:08

Formulating and Characterizing an Exosome-based Dopamine Carrier System

Published on: April 4, 2022

3.7K

Area of Science:

  • Neuroscience
  • Biomarker Discovery
  • Exosome Biology

Background:

  • Current Alzheimer's disease (AD) diagnosis relies heavily on PET imaging for amyloid-β (Aβ) detection.
  • Cerebrospinal fluid (CSF) biomarkers like Aβ, T-Tau, and P-Tau exist, but lack quantitative accuracy.
  • Alpha-synuclein in CSF is a potential neurodegeneration biomarker, but its utility is limited.

Purpose of the Study:

  • To explore the potential of exosomes as neuronal diagnostic components for neurodegenerative diseases.
  • To review current methods for exosome preparation, isolation, and quantification.
  • To discuss the future outlook of exosome-based diagnostics for neurological conditions.

Main Methods:

  • Literature review of exosome isolation techniques.
  • Analysis of exosome quantification methodologies.
  • Evaluation of exosome biomarkers in cerebrospinal fluid.

Main Results:

  • Exosomes offer a promising avenue for liquid biopsy in neurodegenerative disease diagnosis.
  • Current exosome isolation and quantification techniques are being refined for clinical application.
  • Exosomes can potentially carry key biomarkers like alpha-synuclein for improved diagnostic sensitivity.

Conclusions:

  • Exosomes represent a valuable tool for advancing the diagnosis of neurological disorders.
  • Further development in exosome isolation and quantification is crucial for clinical translation.
  • Neuronal exosome-based diagnostics hold significant potential for early and accurate disease detection.