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Updated: Feb 1, 2026

In Silico Clinical Trials for Cardiovascular Disease
Published on: May 27, 2022
[Negative emotions associated with cardiovascular diseases]
1Magatartástudományi Intézet, Semmelweis Egyetem, Általános Orvostudományi Kar Budapest, Nagyvárad tér 4. XX. emelet, 1089.
Insights
Negative emotions like depression and anxiety are linked to cardiovascular diseases. Vital exhaustion and hostility are significant risk factors for heart conditions, with a two-way causal relationship.
Area of Science:
- Cardiology
- Psychiatry
- Behavioral Medicine
Background:
- Negative emotions, including depression, anxiety, vital exhaustion, and hostility, are widely studied in relation to cardiovascular health.
- Specific conditions like generalized anxiety and panic disorder are linked to cardiovascular diseases.
- Vital exhaustion, characterized by loss of energy, irritability, and demoralization, is identified as a precursor to myocardial infarction.
Purpose of the Study:
- To explore the link between negative emotions and cardiovascular diseases.
- To identify vital exhaustion and hostility as significant risk factors for coronary heart diseases.
- To examine the bidirectional causality between negative emotions and cardiovascular diseases.
Main Methods:
- Analysis of patient interviews following myocardial infarction.
- Review of studies on anger suppression and expression in relation to coronary heart diseases.
- Inclusion of interview questions from European Guidelines (2016) for assessing negative emotions.
Main Results:
- Vital exhaustion is a precursor to myocardial infarction and a significant risk factor for coronary heart diseases in both sexes.
- Anger suppression and destructive anger expression are associated with a higher incidence of coronary heart diseases.
- A two-way causal relationship exists between negative emotions and cardiovascular diseases, with low heart rate variability playing a key role.
Conclusions:
- Negative emotions, particularly vital exhaustion and hostility, are crucial risk factors for cardiovascular diseases.
- The relationship between negative emotions and cardiovascular health is bidirectional.
- Tools exist to help estimate negative emotions associated with coronary heart diseases.
Abstract:
With regard to cardiovascular health, the role of negative emotions, particularly that of depression, anxiety, vital exhaustion and hostility has been studied the most widely. Mainly the somatic symptoms of depression and, out of anxiety disorders, generalised anxiety and panic disorder have been linked to cardiovascular diseases. Based on an analysis of interviews of patients having suffered myocardial infarction, it was found that vital exhaustion (a combination of loss of energy, increased irritability, and general demoralization) is a precursor of infarction. Vital exhaustion has proven to contribute to the development of coronary heart diseases, being one of the most important risk factors in both sexes. With regard to hostility, studies show that anger suppression and destructive anger expression (blaming others) are closely linked to a higher incidence of coronary heart diseases. Evidence shows that the relationship between negative emotions and cardiovascular diseases is one of a two-way causality, that is, the presence of a cardiovascular disease may also enhance negative emotions, low heart rate variability playing a crucial role in both diseases. This study also presents interview questions suggested by the European Guidelines (2016) to estimate negative emotions related to coronary heart diseases. Orv Hetil. 2018; 159(48): 2005-2010.
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