[Relation of Thromboelastography with Coagulation Function and Plt Count in Different Coagulation States]

Area of Science:

• Hematology
• Clinical Pathology
• Diagnostic Medicine

Background:

• Thromboelastography (TEG) offers dynamic assessment of blood coagulation.
• Routine coagulation tests and platelet (Plt) counts provide static measures.
• Understanding the correlation between TEG and routine tests is crucial for clinical application.

Purpose of the Study:

• To investigate the correlation and consistency between TEG parameters and routine coagulation tests (PT, APTT, Fib, TT) and Plt counts.
• To analyze these correlations across different coagulation states: hypercoagulable, low coagulation, and normal coagulation.
• To evaluate the clinical utility of TEG compared to routine tests for monitoring blood coagulation.

Main Methods:

• Retrospective analysis of 409 patients' clinical data from January 2015 to December 2017.
• Comparison of TEG parameters (R, K, Angle, MA) with routine tests (PT, APTT, Fib, TT) and Plt counts.
• Statistical analysis included Pearson correlation, Kappa consistency, and paired chi-square tests across different coagulation states.

Main Results:

• TEG parameters (R, K, Angle, MA) showed varying degrees of correlation with routine coagulation tests and Plt counts.
• Correlation and consistency differed significantly across low, normal, and high coagulation states.
• For instance, R value correlated positively with PT and APTT, while K value negatively correlated with Fib and Plt count.

Conclusions:

• TEG demonstrates correlation with routine blood coagulation tests and platelet detection.
• The degree of correlation and consistency varies depending on the patient's coagulation status.
• TEG is recommended for patients with potential hyper- or hypocoagulation to dynamically monitor coagulation, guide therapy, and reduce risks.