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Updated: Feb 1, 2026

Author Spotlight: Metallic Nanocomposites to Eliminate Antibiotic-Resistant Bacteria
Published on: October 4, 2024
Synthesis of Biogenic Copper Nanoparticles Embedded in Graphene Oxide-Chitosan Composite and Its Anti-Bacterial and
Subramanian Mugesh1, Renganathan Arun1, Kulanthaiyesu Arunkumar2
1Department of Microbial Technology, School of Biological Sciences, Madurai Kamaraj University, Madurai 625021, Tamilnadu, India.
Abstract:
In the current scenario, nanoparticle synthesis has been fascinated by biogenic approaches than the chemical methods. However, reproducibility of the source stands essentially in nanoparticle synthesis. Nanoparticle synthesis by fungi has more advantages such as the potential for bioaccumulation, immunity towards toxicity, relatively easier to handle, simpler in synthesis and downstream processing. In this study, biogenic copper nanoparticles (CuNPs) were embedded within graphene oxide-chitosan (GO-CS) polymer to endure the biocompatibility and toxicological effects on both normal and cancer cells. The characteristics of the copper nanoparticles/graphene oxide-chitosan (CuNPs/GO-CS) nanocomposites was found to be superior to the GO-CS. This is evident from the results obtained from X-ray diffraction technique, UV-visible spectroscopy, atomic force microscope, fourier transform infrared spectroscopy, fluorescence spectroscopy, confocal laser scanning microscope and scanning electron microscopy. The synthesized new copper nanoparticles/graphene oxide-chitosan (CuNPs/GO-CS) nanocomposites were studied for their anti-bacterial activity against Escherichia coli MTCC 443 and anti-cancer activity on breast cancer MCF7 cell lines.
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