Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Clinical Trials01:16

Clinical Trials

10.5K
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
10.5K
Clinical Trials: Overview01:11

Clinical Trials: Overview

4.9K
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
4.9K
Statistical Software for Data Analysis and Clinical Trials01:12

Statistical Software for Data Analysis and Clinical Trials

1.5K
Statistical software is pivotal in data analysis and clinical trials by providing tools to analyze data, draw conclusions, and make predictions. These software packages range from simple data management applications to complex analytical platforms, supporting various statistical tests, models, and simulation techniques. Their significance lies in their ability to handle vast amounts of data with precision and efficiency, enabling researchers to validate hypotheses, identify trends, and make...
1.5K
Enzymes02:34

Enzymes

94.7K
Inside living organisms, enzymes act as catalysts for many biochemical reactions involved in cellular metabolism. The role of enzymes is to reduce the activation energies of biochemical reactions by forming complexes with its substrates. The lowering of activation energies favor an increase in the rates of biochemical reactions.
Enzyme deficiencies can often translate into life-threatening diseases. For example, a genetic abnormality resulting in the deficiency of the enzyme G6PD...
94.7K
Trial and Error and Algorithm01:12

Trial and Error and Algorithm

411
A problem-solving strategy is a plan of action used to find a solution. Different strategies have distinct action plans. Trial and error involves trying different solutions until one works. For instance, to fix a broken printer, you might check ink levels, ensure the paper tray isn't jammed, and verify the printer's connection to your laptop. This method can be time-consuming but is commonly used. Thomas Edison, for example, used trial and error to find a suitable filament for the light...
411
Self-Efficacy01:29

Self-Efficacy

224
Self-efficacy is the belief in one's capacity to organize and execute actions necessary to manage prospective situations. This belief significantly influences how individuals approach goals, tasks, and challenges across different domains of life.Psychological and Educational ImpactsIndividuals with strong self-efficacy are more resilient in the face of difficulties. They are more likely to adopt effective problem-solving strategies, persist through obstacles, and regulate emotions such as...
224

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Statistical methods for retrospective harmonization of longitudinal epidemiological data: a scoping review.

European journal of epidemiology·2026
Same author

Dietary intake, nutritional status and healthcare characteristics of mothers and newborn infants in a prospective cohort study (CHAMP) from a malnutrition-endemic region of Pakistan.

Frontiers in nutrition·2026
Same author

Effectiveness of monovalent rotavirus vaccine among young children in Pakistan: a test-negative case-control evaluation.

Vaccine·2026
Same author

Tau pathological activity in plasma before the onset of symptomatic Alzheimer's disease.

medRxiv : the preprint server for health sciences·2026
Same author

Biomarkers.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Reference Curves for Metabolic Syndrome Indicators in Children and Adolescents: A Global Systematic Review.

Current obesity reports·2026

Related Experiment Video

Updated: Feb 1, 2026

Assessment of the Efficacy of An Osteopathic Treatment in Infants with Biomechanical Impairments to Suckling
07:11

Assessment of the Efficacy of An Osteopathic Treatment in Infants with Biomechanical Impairments to Suckling

Published on: February 5, 2019

9.7K

Clinical Efficacy Of Lactase Enzyme Supplement In Infant Colic: A Randomised Controlled Trial.

Mubashir Ahmed1, Abdul Gaffar Billoo2, Khalid Iqbal3

  • 1Kharadar General Hospital, Karachi.

JPMA. the Journal of the Pakistan Medical Association
|December 4, 2018
PubMed
Summary

Lactase enzyme supplements significantly reduced crying duration in infants with colic. This randomized clinical trial found a notable improvement in colic symptoms after a two-week intervention with lactase enzyme.

Keywords:
Infant, Colic, Excessive crying, Lactose intolerance, Lactase

More Related Videos

Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment
08:36

Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment

Published on: April 19, 2024

1.2K
Measuring Lactase Enzymatic Activity in the Teaching Lab
04:41

Measuring Lactase Enzymatic Activity in the Teaching Lab

Published on: August 6, 2018

116.6K

Related Experiment Videos

Last Updated: Feb 1, 2026

Assessment of the Efficacy of An Osteopathic Treatment in Infants with Biomechanical Impairments to Suckling
07:11

Assessment of the Efficacy of An Osteopathic Treatment in Infants with Biomechanical Impairments to Suckling

Published on: February 5, 2019

9.7K
Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment
08:36

Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment

Published on: April 19, 2024

1.2K
Measuring Lactase Enzymatic Activity in the Teaching Lab
04:41

Measuring Lactase Enzymatic Activity in the Teaching Lab

Published on: August 6, 2018

116.6K

Area of Science:

  • Pediatrics
  • Gastroenterology
  • Pharmacology

Background:

  • Infant colic, characterized by excessive crying, affects a significant number of infants.
  • Current management strategies for infant colic have varying degrees of effectiveness.
  • The role of lactase enzyme in alleviating colic symptoms warrants further investigation.

Purpose of the Study:

  • To evaluate the efficacy of lactase enzyme supplementation in managing infant colic.
  • To compare the reduction in crying duration between infants receiving lactase enzyme and those receiving a placebo.

Main Methods:

  • A double-blind, randomized clinical trial involving 104 infants aged 0-6 months diagnosed with infant colic.
  • Infants were randomized into two groups: one receiving lactase enzyme (Colibid) and the other a placebo, for two weeks.
  • Crying duration was recorded at baseline and after one and two weeks of intervention, with statistical analysis at p<0.05.

Main Results:

  • After two weeks, 86.5% of infants in the lactase enzyme group showed significant improvement in crying duration compared to 59.6% in the placebo group.
  • The reduction in crying duration in the lactase enzyme group was statistically significant (p<0.05).
  • No significant difference in crying duration was observed between boys and girls.

Conclusions:

  • Lactase enzyme supplementation demonstrated significant efficacy in reducing crying duration in infants suffering from colic.
  • The findings support the use of lactase enzyme as a potential therapeutic option for infant colic.
  • Further research may explore optimal dosage and long-term effects.