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Related Concept Videos

Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment01:08

Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment

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Hepatic impairment, characterized by decreased liver function, does not uniformly mandate adjustments in drug dosage. Whether dosage modifications are necessary depends on various factors related to the drug's metabolism and elimination pathways. If a drug is primarily excreted via the kidneys and bypasses significant hepatic processing, if it undergoes minimal metabolic transformation in the liver, or if it is volatile and primarily expelled through the lungs, dose adjustments may not be...
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Hepatic Portal System01:21

Hepatic Portal System

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The hepatic portal system, a critical part of our circulatory framework, transports nutrient-laden, deoxygenated blood from the gastrointestinal tract and spleen to the liver. This ingenious system plays an indispensable role in maintaining our body's metabolic equilibrium.
At its core, the hepatic portal vein is the result of a confluence of the superior and inferior mesenteric veins along with the splenic vein. Each of these veins has a unique role. The superior mesenteric vein is...
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Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow01:26

Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow

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Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug...
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Hepatic Drug Excretion: Influencing Factors01:16

Hepatic Drug Excretion: Influencing Factors

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The biliary system of the liver, crucial for bile secretion and drug excretion, comprises intrahepatic bile ducts that merge to form the common hepatic duct. This duct, carrying hepatic bile, combines with the cystic duct, draining the gallbladder and forming the common bile duct, which empties into the duodenum. Bile, produced by hepatic cells lining the bile canaliculi, is composed primarily of water, bile salts, pigments, electrolytes, and lesser amounts of cholesterol and fatty acids. Bile...
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Hepatic Drug Clearance: Role of Transporters01:14

Hepatic Drug Clearance: Role of Transporters

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In the liver and bile canaliculi, influx and efflux transporters modification can influence intrinsic clearance. Transporters play a significant role in moving drugs within liver cells. Elaborate models, such as the Biopharmaceutical Classification System (BCS), are essential to relate transporters to drug disposition. This system categorizes drugs into four classes based on solubility and permeability, providing insights into elimination routes and the effects of transporters following oral...
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Hepatic Drug Excretion: Enterohepatic Cycling01:17

Hepatic Drug Excretion: Enterohepatic Cycling

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Enterohepatic cycling involves the active secretion of drugs and their metabolites into the bile via transporters in the canalicular membrane of hepatocytes. This secretion is an integral part of the digestive process, releasing these substances into the gastrointestinal (GI) tract.
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Related Experiment Video

Updated: Feb 1, 2026

Measurement of the Hepatic Venous Pressure Gradient and Transjugular Liver Biopsy
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Infantile Hepatic Hemangioma.

Zeshan Shabbir1, Ainy Javaid1, 1

  • 1Department of Radiology, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan.

JPMA. the Journal of the Pakistan Medical Association
|December 4, 2018
PubMed
Summary

Infantile hepatic hemangioma (IHH) is a rare condition diagnosed via imaging. This case highlights typical CT findings in a 4-month-old infant presenting with abdominal distention.

Area of Science:

  • Pediatric Radiology
  • Hepatology
  • Vascular Anomalies

Background:

  • Infantile hepatic hemangioma (IHH), a visceral manifestation of infantile hemangioma, was formerly termed hemangioendothelioma.
  • Diagnosis typically relies on characteristic radiological findings.

Observation:

  • A 4-month-old infant presented with significant abdominal distention.
  • Clinical presentation suggested a possible intra-abdominal mass or anomaly.

Findings:

  • Contrast-enhanced computed tomography (CT) revealed diffuse infantile hepatic hemangiomas.
  • Imaging demonstrated widespread, characteristic features of IHH throughout the liver.

Implications:

  • Accurate radiological diagnosis is crucial for appropriate management of IHH.
Keywords:
Infantile hepatic hemangioma, IHH, benign tumour, diffuse type.

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  • Understanding the imaging spectrum aids in differentiating IHH from other pediatric liver conditions.