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Updated: Feb 1, 2026

Measuring TCR-pMHC Binding In Situ using a FRET-based Microscopy Assay
Published on: October 30, 2015
Immunological status of chronically exposed persons with increased level of TCR mutations
A A Akleyev1,2, E A Blinova3,4, Ilya I Dolgushin5
1South Ural State Medical University, Chelyabinsk, Russia. andrey.akleev@yandex.ru.
Abstract:
Dose- and dose rate-dependent increase in the number of СD3+СD16+CD56+-lymphocytes and lysosomal activity of neutrophils was noted in peripheral blood of the Techa riverside residents with increased level of TCR gene-mutated T lymphocytes long after chronic exposure of predominantly red bone marrow (mean exposure dose was 0.89 ± 0.09 Gy, individual dose range was 0.09-1.96 Gy). The performed analysis showed that the above-mentioned immunological changes could be a response to an increase in the frequency of mutations (TCR mutations in particular) in the cells of exposed individuals.
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