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Cataract surgery in ocular cicatricial pemphigoid
M Sainz de la Maza1, J Tauber, C S Foster
1Immunology Service, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston 02114.
Ophthalmology
|April 1, 1988
Summary
Cataract surgery in patients with cicatricial pemphigoid is safe after inflammation control. Vision improved significantly, with no disease progression observed in this study.
Area of Science:
- Ophthalmology
- Immunodermatology
Background:
- Cicatricial pemphigoid is an autoimmune blistering disease that can affect the eyes.
- Ocular cicatricial pemphigoid often leads to significant visual impairment due to conjunctival inflammation and scarring.
Purpose of the Study:
- To evaluate the safety and efficacy of cataract surgery in patients with biopsy-proven ocular cicatricial pemphigoid.
- To assess the impact of cataract surgery on disease progression and visual outcomes in this patient population.
Main Methods:
- Retrospective case series of 20 patients (26 eyes) with cicatricial pemphigoid undergoing cataract surgery.
- Patients were on systemic immunosuppression and received perioperative corticosteroids.
- Pre- and postoperative evaluations included conjunctival inflammation, cicatrization, keratopathy, and disease staging.
Main Results:
- No patient experienced progression in cicatricial pemphigoid disease stage postoperatively.
- Average visual acuity improved by 3.5 Snellen lines.
- Worse outcomes were linked to chemotherapy intolerance or preoperative conjunctival inflammation.
Conclusions:
- Cataract surgery can be safely performed in patients with cicatricial pemphigoid once conjunctival inflammation is controlled.
- Successful management of ocular inflammation is crucial for favorable surgical outcomes.