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Updated: Feb 1, 2026

A Contrast of Three Inoculation Techniques used to Determine the Race of Unknown Fusarium oxysporum f.sp. niveum Isolates
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A Contrast of Three Inoculation Techniques used to Determine the Race of Unknown Fusarium oxysporum f.sp. niveum Isolates

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Fusarium oxysporum is an onychomycosis etiopathogenic agent

Flávia F Veiga1, Lidiane V de Castro-Hoshino2, Francielle Sato2

  • 1Departamento de Análises Clínicas e Biomedicina, Universidade Estadual de Maringá (UEM), Avenida Colombo, 5790, Maringá, PR, CEP 87020-900, Brazil.

Future Microbiology
|December 4, 2018
PubMed
Abstract

Insights

Fusarium oxysporum infects human nails, forming a biofilm and suggesting it as a primary cause of fungal nail infections (onychomycosis). This ex vivo study highlights nail structure

Area of Science:

  • Medical Mycology
  • Dermatology
  • Infectious Diseases

Background:

  • Onychomycosis is a common nail fungal infection.
  • The etiopathogenesis of Fusarium-induced onychomycosis requires further elucidation.

Purpose of the Study:

  • To investigate the etiopathogenesis of Fusarium oxysporum causing onychomycosis.
  • To characterize fungal-nail interactions in an ex vivo human nail model.

Main Methods:

  • Ex vivo human nail fragments were used.
  • Infection and invasion were assessed using scanning electron microscopy (SEM), CFU counts, histopathology, and FTIR-ATR spectroscopy.

Main Results:

  • Fusarium oxysporum infected and invaded nail fragments irrespective of the application surface.
  • The ventral nail surface was more susceptible to invasion than the dorsal surface.
  • A dense fungal biofilm formed upon interaction between Fusarium oxysporum and the nail.

Conclusions:

  • Fusarium oxysporum can infect and invade healthy human nails, leading to biofilm formation.
  • These findings suggest Fusarium oxysporum as a potential primary agent of onychomycosis.
Keywords:
biofilmnailonychomycosis

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