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Hyperhydration-Induced Decrease in Urinary Luteinizing Hormone Concentrations of Male Athletes in Doping Control

Ioanna Athanasiadou1,2, Sven Christian Voss1, Wesal El Saftawy1

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|December 4, 2018
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Summary
This summary is machine-generated.

Hyperhydration significantly dilutes urine, potentially masking anabolic steroid abuse by lowering luteinizing hormone (LH) levels. Adjusting LH by specific gravity can correct for this dilution effect in doping control.

Keywords:
endogenous substancesexcessive fluid intakemaskingspecific gravityurinary excretion

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Area of Science:

  • Sports Science
  • Biochemistry
  • Doping Control

Background:

  • Low urinary luteinizing hormone (LH) levels are investigated as a marker for steroid abuse.
  • Urine dilution can misleadingly indicate anabolic steroid abuse by suppressing LH concentrations.

Purpose of the Study:

  • To assess the impact of hyperhydration on interpreting LH findings in doping control.
  • To explore methods for correcting volume-related changes in urinary LH concentrations.

Main Methods:

  • Seven healthy males underwent a 72-hour hyperhydration protocol using water and a sports drink.
  • Urine samples were analyzed following World Anti-Doping Agency (WADA) guidelines.
  • Urinary LH concentrations were measured and compared to baseline values.

Main Results:

  • Hyperhydration significantly decreased urinary LH concentrations (p < .001).
  • This decrease suggests a clear dilution effect from hyperhydration.
  • Adjusting LH by specific gravity (reference 1.020) effectively corrected for hyperhydration-induced decreases.

Conclusions:

  • Hyperhydration can significantly alter urinary LH levels, potentially affecting doping control results.
  • Specific gravity adjustment is a viable method to correct for dilution effects in urinary LH measurements.
  • Accurate doping control requires accounting for hydration status to prevent misinterpretation of steroid abuse markers.