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Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia
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Clinical significance of Janus Kinase inhibitor selectivity

Ernest H Choy1

  • 1CREATE Centre, Section of Rheumatology, Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff, UK.

Rheumatology (Oxford, England)
|December 4, 2018
PubMed

Insights

Janus Kinase (JAK) inhibitors offer a new oral therapy for rheumatoid arthritis (RA) by targeting inflammation. This review examines the efficacy, safety, and selectivity of JAK inhibitors in RA treatment.

Area of Science:

  • Immunology
  • Pharmacology
  • Rheumatology

Background:

  • Cytokines are central to rheumatoid arthritis (RA) inflammation.
  • Anti-cytokine therapies have improved RA outcomes.
  • Janus Kinases (JAK) mediate cytokine receptor signaling.

Purpose of the Study:

  • To review the efficacy and safety of oral JAK inhibitors (JAKi) in RA.
  • To explore the clinical significance of JAKi selectivity.

Main Methods:

  • Review of existing literature on JAK inhibitors in RA.
  • Analysis of efficacy and safety data for approved and developing JAKi.
  • Discussion of JAK isoform selectivity and its therapeutic implications.

Main Results:

  • Oral JAK inhibitors are effective in treating RA.
  • Tofacitinib and baricitinib are approved JAKi for RA.
  • JAK inhibitors exhibit varying selectivity profiles, impacting their clinical use.

Conclusions:

  • JAK inhibitors represent a significant advancement in RA anti-cytokine therapy.
  • Understanding JAKi selectivity is crucial for optimizing RA treatment.
  • Further research into JAK inhibitor development and application is ongoing.
Keywords:
DMARDsJanus Kinaserheumatoid arthritistargeted synthetic DMARDstreatment

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