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Synthesis of Indoxyl-glycosides for Detection of Glycosidase Activities
Published on: May 27, 2015
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New Phenolic Glycosides from Physalis angulata
Natural Product Communications
|December 4, 2018
Summary
Two new compounds, physangulosides A and B, were isolated from Physalis angulata. These natural products offer weak protection against liver cell damage caused by hydrogen peroxide.
Area of Science:
- Phytochemistry
- Natural Products Chemistry
- Pharmacology
Background:
- Physalis angulata, a traditional medicinal plant, contains various bioactive compounds.
- Phenolic glycosides are a class of natural products with diverse biological activities.
- Hepatocytes are liver cells susceptible to oxidative stress-induced damage.
Purpose of the Study:
- To isolate and characterize new phenolic glycosides from Physalis angulata.
- To evaluate the protective effects of the isolated compounds against hydrogen peroxide-induced liver cell damage.
Main Methods:
- Isolation of compounds using chromatographic techniques.
- Structure elucidation employing High-Resolution Electrospray Ionization Mass Spectrometry (HR-ESI-MS) and 1D/2D Nuclear Magnetic Resonance (NMR) spectroscopy.
- Assessment of hepatoprotective activity in vitro using cell-based assays.
Main Results:
- Two novel phenolic glycosides, designated physangulosides A and B, were successfully isolated.
- The chemical structures of physangulosides A and B were confirmed through comprehensive spectroscopic analysis.
- Both physangulosides A and B demonstrated weak hepatoprotective effects against oxidative stress.
Conclusions:
- Physalis angulata is a source of novel phenolic glycosides.
- Physangulosides A and B possess mild antioxidant properties relevant to hepatoprotection.
- Further research may explore the potential of these compounds or their derivatives for liver health.
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