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Related Experiment Video

Updated: Feb 1, 2026

Author Spotlight: Advanced Integrated Model for Sepsis-Induced Myopathy and Single-Cell Metabolic Analysis

Author Spotlight: Advanced Integrated Model for Sepsis-Induced Myopathy and Single-Cell Metabolic Analysis

Published on: June 14, 2024

[Simvastatin-Induced Myopathy after Dose Increase].

Imke Kandzia¹, Michael Kowar¹, Monika Frackowiak¹

¹Klinik für Geriatrie mit Neurologie und Tagesklinik, Johanniter-Krankenhaus Bonn, Johanniter GmbH.

Deutsche Medizinische Wochenschrift (1946)

|December 4, 2018

Summary

Statin medication can cause myopathy and rhabdomyolysis, leading to leg weakness. Promptly stopping statins and providing fluids can reverse these effects, restoring muscle function.

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Published on: September 24, 2021

Area of Science:

Neurology
Pharmacology
Biochemistry

Background:

A case study of an 86-year-old patient with hypercholesterolemia treated with Simvastatin.
The patient experienced a dosage increase of Simvastatin from 40 to 80 mg six months prior due to elevated cholesterol levels.

Observation:

The patient presented with progressive weakness in the right leg.
Elevated creatinine kinase and creatinine levels were observed.
Electromyography (EMG) revealed neuromuscular impairment.

Findings:

Diagnosis of statin-induced myopathy with rhabdomyolysis was confirmed.
Discontinuation of statin therapy and fluid substitution led to a decrease in creatinine kinase and creatinine levels.
Complete resolution of leg weakness was observed after treatment.

Implications:

Highlights the potential for statin-induced myopathy and rhabdomyolysis.
Emphasizes the importance of considering myopathy in patients with neurological symptoms while on statin therapy.
Underscores the effectiveness of early diagnosis and intervention, including statin cessation and supportive care.